依托咪酯与异丙酚用于门诊无痛人流的临床效能比较  

Comparison of clinical effect between etomidate and propofol in analgesic artificial abortion

作　　者：黄东林[1] 修玉芳[1] 肖龙[1] 

机构地区：[1]大连市妇产医院麻醉科,辽宁大连116033

出　　处：《第四军医大学学报》2009年第18期1800-1801,共2页Journal of the Fourth Military Medical University

摘　　要：目的:比较依托咪酯和异丙酚用于门诊无痛人流术的临床效能.方法:选择门诊孕期38～85 d的自愿终止妊娠的患者200例,ASAⅠ～Ⅱ级,随机分为两组(每组100例).麻醉采用静注力月西1 mg,1 min后静注芬太尼2μg/kg,随后注入A组异丙酚2 mg/kg,B组依托咪酯0.2 mg/kg,监测记录MAP,心率(HR),脉搏血氧饱和度(SpO2),观察记录术中镇痛效果,术后恢复时间及静脉注射痛发生率.结果:两组术中镇痛效果及术后恢复时间无明显差异,A组MAP,HR明显下降(P<0.05),A组静脉注射痛发生率显著高于B组(P<0.05).结论:依托咪酯和异丙酚均可为无痛人流术提供有效的麻醉.但依托咪酯具有血流动力学稳定、静脉注射痛发生率低的优点.AIM： To compare the clinical effect of etomidate and propofol used for analgesic artificial abortion. METHODS： Two hundred clinical volunteers of termination of 38-to-85-day pregnancy （ASA Ⅰ - Ⅱ grade ） were randomly divided into 2 groups, with 100 subjects in each group. After 1 mg midazolam followed by 2 ug/kg fentanyl 1 min later, the subjects in group A received 2 mg/kg propofol and the subjects in group B received 0.2 mg/kg etomidate. The levels of MAP, HR and SpO2 were monitored and recorded at three time points during anesthesia, and the intraoperative analgesic effect, the postoperative recovery time and the occurrence rate of intravenous injection pain of the 2 groups were recorded. RESULTS： No significant differences were observed in the intraoperative analgesic effect and the postoperative recovery time between the 2 groups. The levels of MAP, HR and SpO2 in group A significantly declined （ P 〈 0.05 ） and the occurrence rate of intravenous injection pain in group A was notably higher than that in group B （ P 〈 0.05 ）. CONCLUSION ： Both etomidate and propofol are effective for analgesic artificial abortion. But etomidate has the advantages of stable blood hemodynamics and lower rate of intravenous injection pain.

关 键 词：依托咪酯 异丙酚 人工 流产 芬太尼 

分 类 号：R719.3[医药卫生—妇产科学]