替米沙坦与非洛地平对原发性高血压纤溶系统的影响  

Effects of Telmisartan and Felodipine on the fibrinolytic system in essential hypertension

作　　者：欧阳迎春[1] 余琴[1] 魏宗德[1] 

机构地区：[1]泸州医学院附属医院心内科,四川泸州646000

出　　处：《华西药学杂志》2009年第5期549-550,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的比较替米沙坦和非洛地平对原发性高血压患者纤溶系统的影响。方法60例原发性高血压患者随机均分为替米沙坦组和非洛地平组,观察治疗后血压、血浆组织型纤溶酶原激活物(tPA)及其抑制物(PAI-1)含量、D-二聚体(D-D)和血管性血友病因子(vWF)水平的变化。结果两组患者治疗后血压均显著下降(P<0.01),PAI-1、vWF和D-D水平均显著性下降(P<0.05),tPA和tPA/PAI-1比值明显升高(P<0.05)。组间D-D和vWF水平无显著差异,替米沙坦组PAI-1含量减少更明显、tPA和tPA/PAI-1比值增加更显著。结论替米沙坦和非洛地平缓释片均能有效改善原发性高血压的纤溶障碍,但替米沙坦优于非洛地平。OBJECTIVE To compare the effect of tehnisartan and felodipine on the fibrinolytic system in essential hypertension （EH）. METHODS 60 patients were randomly received telmisartan （ 80mg· d^-1 ） or felodipine （5 mg· d^-1 ） for 4 weeks. Plasma tissue plasminogen activator （tPA） antigen, tissue plasminogen activator inhibitor - 1 （ PAI - 1 ） antigen, D - dimer（ D - D） and yon Willebrand factor（vWF） level were measured before and 4 weeks after administration. Blood pressure were also measured at the same time. RESULTS In both hypertensive group,blood pressure was significantly reduced to a similar level after drug treatment. In the two hypertensive groups, plasma PAI - 1, vWF and D - D level significantly decreased, but tPA and tPA/PAI - 1 ratio significantly increased after drug treatment. Between two hypertensive group, PAI- 1 antigen level was significantly lower in telmisartan group, and tPA/PAI - 1 ratio was significantly higher than that in felodipine group after drug treatment. CONCLUSION Both telmisartan and felodipine improved impaired fibrinolysis in essential hypertension, but telmisartan was better than felodipine.

关 键 词：高血压 纤维蛋白溶解 纤溶酶原激活物抑制剂 替米沙坦 非洛地平 

分 类 号：R96[医药卫生—药理学]