老年恶性肿瘤患者放化疗期间医院感染的临床分析  

Nosocomial Infection in Old Inpatients with Cancer During Radiotherapy and Chemotherapy:A Clinical Analysis

作　　者：金璋[1] 王海英[1] 沈洁[1] 

机构地区：[1]温州市第二人民医院放疗科,浙江温州325000

出　　处：《中华医院感染学杂志》2009年第20期2704-2706,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查老年恶性肿瘤患者放化疗期间医院感染状况,并对其相关因素进行分析。方法对临床2005年l月-2008年10月,236例恶性肿瘤放化疗期间发生医院感染的老年患者进行回顾性调查,数据采用χ2检验判断差异是否具有统计学意义。结果老年恶性肿瘤患者放化疗期间医院感染率为44.36%,男女性别之间差异无统计学意义,其中以肺部原发肿瘤医院感染率最高为69.39%;放疗结合化疗医院感染率较高为56.96%;感染部位绝大多数为呼吸道占51.27%;医院感染率与住院时间呈正相关,随着住院天数的增加,感染率增高;营养状况差、肿瘤期别高、进行侵入性操作、白细胞低下、使用抗菌药物容易引起医院感染。结论老年恶性肿瘤患者放化疗期间医院感染的发生率明显高于老年普通疾病,也高于非老年恶性肿瘤患者,医院感染的发生与原发肿瘤部位、治疗方式、住院时间长短等因素有关。OBJECTIVE To investigate and analyze the incidence and related factors of nosocomial infection in old inpatients with cancers during radiotherapy and chemotherapy. METHODS Retrospective surveys of nosocomial infection were carried out in 236 old inpatients with cancers from Jan 2005 to Oct 2008. χ^2 Test was used to evaluate the difference significance of the data. RESULTS The surveys indicated the infection rate was 44.36 % and without the sex difference. The infection rate among old inpatients with lung cancer was the highest and counted for 69.39 % and then with radiotherapy and chemotherapy that was 56.96 %. Respiratory infection was the main infection and counted for 51.27%. The hospital stay time correlated well with the infection rate of the inpatients. With the hospital stay time increasing, the infection rate also increased. Moreover, the predisposing factors of inpatients infection included poor nutrition, advanced stage of tumors, aggressive procedures, leukopenia and application of antibiotics. CONCLUSIONS The nosocomial infection rate of old inpatients with cancers during radiotherapy and chemotherapy is much higher than that of the elders with common diseases and that of the youngers with cancers. The incidence of nosocomial infection is related to the sites of the primary cancers, therapy methods, hospital stay, etc. We must emphasize and control the predisposing factors effectively, and reduce the occurrence of nosocomial infection.

关 键 词：恶性肿瘤 放疗 化疗 医院感染 

分 类 号：R181.32[医药卫生—流行病学]