丹参注射液中丹酚酸B对丹参素药代动力学影响  

Effects of salvianolic acid B on the pharmacokinetics of danshensu in Danshen injection in rats

作　　者：余丹[1] 柴建国 曹彦光[1] 陈渊成[1] 柳晓泉[1] 

机构地区：[1]中国药科大学药物代谢与动力学研究中心,南京210009 [2]正大青春宝药业有限公司,杭州310023

出　　处：《中国药科大学学报》2009年第3期258-262,共5页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30772609)~~

摘　　要：目的:研究丹参注射液中丹酚酸B对丹参素药动学行为的影响。方法:大鼠分别静脉注射丹参注射液以及丹参注射液外加丹酚酸B,血浆药动学研究中另外增加了丹参素组及丹参素外加丹酚酸B组,用LC/MS法测定血浆和心、肝、肾、肺等各组织以及尿液中丹参素的浓度。结果:在丹参注射液中外加丹酚酸B能显著增加丹参素在大鼠血浆中的暴露程度,而在丹参素中外加丹酚酸B对丹参素的药动学行为却无显著影响,与丹参注射液组相比,大鼠给予丹参注射液外加丹酚酸B单体后,丹参素在肾脏的分布下降,在尿中排泄的减少,这可能是引起血浆药动学变化的原因之一。结论:丹参注射液复杂体系存在的情况下,丹酚酸B对丹参素药动学行为产生显著影响,提示中药复杂成分间药动学相互作用与中药复杂体系整体性存在与否密切相关。Aim： To study the pharmacokinetic effects of salvianolic acid B（ Sal B） on danshensu（DSS） in Danshen injection in rats. Method： Following the intravenous administration of Danshen injection and Danshen injection added with Sal B to rats, the plasma kinetic study, tissue distribution and urine excretion were studied. The plasma kinetic study was also investigated by giving DSS and DSS in combination with Sal B to rats. Plasma, tissue and urine drug levels of danshensu were analyzed by LC-MS. Results： Compared with danshensu given alone, no significant difference of the pharmacokinetic behavior of danshensu was found when danshensu was given in combination with salvianolic acid B. However, compared with Danshen injection given alone, the pharmacokinetic behavior of danshensu changed remarkably when Danshen injection was given in combination with salvianolic acid B which might be caused by the decrease of DSS in kidney distribution and urine excretion. Conclusion： The pharmacokinetic effects of salvianolic acid B on danshensu depend on the existence of multiple components in Dansh- en injection. Results suggest that the pharmacokinetic interactions of the multiple components are closely related to the integrity of herbal medicines.

关 键 词：丹参注射液 丹参素 丹酚酸B 药动学 整体性 

分 类 号：R285[医药卫生—中药学]