人参茎叶皂苷对实验性小鼠心电改变及死亡时间的影响  

Effects of Ginseng Stem Leaf Glucoside on Mouse Arrhythmia and Death Time

作　　者：唐泽耀[1] 唐田田[1] 付雷[2] 汤玉仪[1] 项媛媛[1] 范鸿博[1] 林原[1] 

机构地区：[1]大连医科大学药理教研室,大连116044 [2]大连医科大学机能实验室,大连116044

出　　处：《实验动物科学》2009年第4期4-7,共4页Laboratory Animal Science

基　　金：国家自然科学基金:平滑肌肌球蛋白活性的双向调节研究项目(批准号:30772601)

摘　　要：目的研究人参茎叶皂苷对实验性心律失常的作用。方法在氯仿和乌头碱诱发的两种小鼠心律失常模型上,分别观察人参茎叶皂苷的抗心律失常作用。结果人参茎叶皂苷对氯仿诱发的小鼠心律失常具有抗心律失常作用,对乌头碱诱发的小鼠心律失常有预防作用,并呈剂量依赖关系。结论人参茎叶皂苷对两种方法诱发的心律失常都具有对抗作用。Objective To investigate the effect of Ginseng stem leaf glucoside on arrhythmia in laboratory mice. Methods Mouse arrhythmia was induced by chloroform or aconitine, and the effect of Ginseng stem leaf glucoside on antiarrhythmia was examined. Results Ventricular arrhythmia induced by chloroform or aconitine was inhibited and the death time was delayed by Ginseng stem leaf glucoside in a dose dependent manner. Conclusion Ginseng stem leaf glucoside can antagonize arrhythmia induced by chloroform or aconitine.

关 键 词：人参 皂苷 氯仿 乌头碱 心律失常 

分 类 号：R59[医药卫生—内科学]