慢性心力衰竭患者血浆尾加压素Ⅱ及肾上腺髓质素的变化  

The changes of plasma urotensin Ⅱ and adrenomedullin in patients with chronic heart failure

作　　者：游卫华 王评[2] 张凤玲[3] 刘晓剑 李茂清[2] 

机构地区：[1]茂名市中医院心血管内科,广东茂名525000 [2]广州中医药大学,广州510405 [3]南宁市第二人民医院心电图科,南宁530031

出　　处：《岭南心血管病杂志》2009年第3期191-194,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的研究慢性心力衰竭患者血浆尾加压素Ⅱ(urotensinⅡ,UⅡ)、肾上腺髓质素(adrenomedullin,ADM)浓度的变化并探讨其临床意义。方法测定90例心力衰竭患者(心力衰竭组)治疗前后血浆UⅡ、ADM浓度及左心室射血分数(left ventricular ejection fraction,LVEF)、左心室质量指数(left ventricular mass index,LVMI)变化,进行相关分析,并与60名健康人(对照组)对照。结果心力衰竭组血浆ADM、UⅡ浓度均显著高于对照组,差异有统计学意义[(38.22±8.28)ng/L比(17.58±3.43)ng/L,P<0.01;(3.29±0.92)pmol/L比(1.85±0.45)pmol/L,P<0.01];心力衰竭组血浆UⅡ浓度与心功能级别正相关(r=0.765,P<0.01),与LVEF负相关(r=-0.681,P<0.01),与LVMI正相关(r=0.705,P<0.01),与血浆ADM浓度正相关(r=0.718,P<0.01);心力衰竭患者治疗后血浆ADM、UⅡ浓度比治疗前显著降低,差异有统计学意义[(29.61±6.88)ng/L比(38.31±8.11)ng/L,P<0.01;(2.52±0.49)pmol/L比(3.43±1.02)pmol/L,P<0.01]。结论血浆ADM和UⅡ浓度随心力衰竭加重而升高,UⅡ、ADM共同参与了心力衰竭的病理生理过程;血浆UⅡ浓度可作为判断心力衰竭严重程度和临床评价心力衰竭治疗效果的生物学指标。Objectives To observe the changes of the concentration of urotensin Ⅱ （ U Ⅱ ） , adrenomedullin （ADM） in plasma in patients with chronic heart failure （CHF） and their clinical implications. Methods The concentration of U Ⅱ , ADM in plasma and the left ventricular ejection fraction （LVEF）, left ventricular mass index （LVMI） of 90 patients with CHF （CHF group） and 60 healthy subjects （control group） were measured and analyzed. Results The concentration of U Ⅱ , ADM in plasma were significantly higher in the CHF group than in the eontrolgroup [（38.22±8.28） ng/Lvs. （17.58±3.43） ng/L, P〈0.01; （3.29±0.92） pmol/Lvs. （1.85±0.45） pmol/L, P〈0.01 ] ; The levels of plasma U Ⅱ and ADM increased parallel with the severity of heart failure ; The concentration of U Ⅱ in plasma negatively correlated with LVEF, and positively correlated with LVMI and ADM; Compared before and after treatment, there were significant differences in CHF patients with ADM and U Ⅱ [ （29.61±6.88） ng/L vs. （38.31±8.11） ng/L, P〈0.01; （2.52±0.49） pmol/Lvs. （3.43±1.02） pmol/L, P〈0.01]. Conclusions The concentration of U Ⅱ , ADM in plasma increased with the severity of heart failure. U Ⅱ , ADM fellowship CHF pathology physiological process. The concentration of U Ⅱ in plasma in CHF patients may serve as an index of the severity of CHF and the assessment for treatment effect.

关 键 词：心力衰竭 尾加压素Ⅱ 肾上腺髓质素 冠状动脉疾病 

分 类 号：R541.6[医药卫生—心血管疾病]