合成受体与短肽相互作用研究进展  

Interaction of Synthetic Receptor with Oligopeptide

作　　者：赵建新[1] 乔义涛[1] 袁直[1] 

机构地区：[1]南开大学化学学院高分子化学研究所功能高分子材料教育部重点实验室,天津300071

出　　处：《化学进展》2009年第10期2123-2131,共9页Progress in Chemistry

基　　金：国家自然科学基金项目(No.50573034;No.20634030)资助

摘　　要：由于在蛋白质分离、生物传感器、疾病诊断和治疗以及基础的生物医药研究等领域的潜在重要应用,合成受体与短肽(3—20氨基酸残基)相互作用的研究已引起了人们的关注。本文综述了近年来合成受体与短肽相互作用的研究进展,介绍了小分子受体与个别氨基酸残基的相互作用,小分子受体对短肽的序列选择性识别,小分子受体对短肽二级结构的诱导与识别以及高分子受体与短肽的相互作用,并对短肽受体的设计进行了建议与展望。Due to their potential important applications for the separation of protein, the use in biosensors, the development of biomedical diagnostics, the treatment of human diseases and the basic biomedical research, the recent progress in the interaction studies of synthetic receptor with interaction of small molecule with individual amino acid residue, small molecule, the inducement and recognition for oligopeptide of with oligopeptide. In addition, the challenges, as well as the oligopeptide is reviewed. This review introduces the the sequence selective recognition for oligopeptide of small molecule and the interaction studies of polymer suggestions to further development of the design of oligopeptide receptors are outlined.

关 键 词：肽 相互作用 合成受体 分子设计 分子识别 

分 类 号：O629.7[理学—有机化学] O641.3[理学—化学]