丹红注射液与维生素B6注射液配伍液中酚酸类成分的稳定性考察  

STUDY ON COMPATIBLE STABILITY OF PHENOLIC ACID COMPOUNDS IN DANHONG INJECTION MIXED WITH VITAMIN B6 INJECTION

作　　者：刘伟娜[1] 杜秀芳[1] 张梅兰 袁志芳[1] 吴海燕[1] 刘敏 

机构地区：[1]河北医科大学药学院实验中心,河北石家庄050017 [2]河北省直属机关第二门诊部,河北石家庄050051

出　　处：《河北医科大学学报》2009年第6期582-584,共3页Journal of Hebei Medical University

基　　金：河北省中医药局科学研究课题(2007152)

摘　　要：目的考察丹红注射液与维生素B6注射液在0.9%氯化钠注射液中配伍的稳定性。方法采用高效液相法梯度洗脱测定配伍液中丹参素、原儿茶醛、丹酚酸B的含量,并测定其24 h内在25℃的pH值。结果丹红注射液与维生素B6注射液配伍后的pH值基本稳定,主要成分丹参素、原儿茶醛和丹酚酸B的含量均无显著变化。结论丹红注射液与维生素B6注射液配伍后pH值和丹参素、原儿茶醛、丹酚酸B的质量基本稳定。Objective To study the stability of Danhong injection mixed with vitamin B6 injection in 0. 9% sodium chloride injection. Methods The contents of danshensu, protocatechuic aldehyde and salvianolic acid B was determined with gradient elution by high performance liqied chromatography,and pH of the solution at 25℃ was determined within 24 hours. Results No significant differences were found in pH and the contents of danshensu,protoeatechuic aldehyde and salvianolic acid B after danhong injection was mixed with vitamin B6 injection. Conclusion pH and the quality of danshensu, protocatechuic aldehyde and salvianolic acid B is stabile in the mixed solution.

关 键 词：色谱法 高压液相 维生素B6 丹参素 

分 类 号：R965[医药卫生—药理学]