γ-氨基丁酸等药物对日本血吸虫运动性的影响  

THE EFFECTS OF GABA ETC ON THE MOTOR ACTIVITY IN SCHISTOSOMA JAPONICA

作　　者：史晓丽[1] 王丽平[1] 沈丽琳[1] 

机构地区：[1]南京农业大学动物医学院

出　　处：《畜牧与兽医》1998年第5期204-206,共3页Animal Husbandry & Veterinary Medicine

摘　　要：采用肉眼观察法测定有关药物对日本血吸虫运动性的影响。结果表明：（１）１０－３，１０－４，１０－５ｍｏｌ／Ｌγ－氨基丁酸（ＧＡＢＡ）均有兴奋虫体的作用，其兴奋性随浓度递增而增强；（２）用１０－３、１０－４ｍｏｌ／Ｌ巴氯酚（ｂａｃｌｏｆｅｎ）、毕扣扣林（ｂｉｃｕｃｕｌｉｎｅ）和印防己毒素（ｐｉｃｒｏｔｏｘｉｎ）作用虫体后，巴氯酚、毕扣扣林在浓度为１０－３ｍｏｌ／Ｌ时对虫体有明显抑制作用，浓度为１０－４ｍｏｌ／Ｌ时抑制作用不明显；而１０－３、１０－４ｍｏｌ／Ｌ印防己毒素均表现一定的兴奋作用；（３）先用１０－３ｍｏｌ／ＬＧＡＢＡ兴奋虫体后，再加入上述药物，结果仍是相同。表明一定浓度的巴氯酚，毕扣扣林不仅对内源性的ＧＡＢＡ有拮抗作用，而且对外源性的ＧＡＢＡ有拮抗性；而印防己毒素不仅无拮抗性，还有协同ＧＡＢＡ的兴奋作用。初步判定，ＧＡＢＡ为日本血吸虫的一种兴奋性神经递质，有别于其它寄生虫（如曼氏血吸虫和鸡蛔虫）。Motor activity was determined with drugs at different concentration under a microscope.The results showed that S.japonica couldbe stimulated by GABA(10 -3 、10 -4 、10 -5 mol/L)while baclofen and bicuculline at concentration around 10 -3 mol/L not only blocked the effects of endogenous GABA but also deduced effects of exogenous GABA.To our interests,picrotoxin did not inhibit the motor activity but had coordinated excitation all along.The above effects preliminarily suggested that GABA is the excitatory transmitter in S.japonica different from other parasites such as S mansoni and A galli etc(GABA is the inhibitory transmitter)

关 键 词：日本血吸虫 Γ-氨基丁酸 运动性 血吸虫病 

分 类 号：R532.21[医药卫生—内科学]