255例老年人尿羟脯氨酸含量的调查  

An investigation on urinary hydroxyproline content in the elderly

作　　者：唐志毅[1] 王振刚[1] 尉秀荣[1] 冯树梅[1] 杨振华[1] 

机构地区：[1]卫生部北京医院检验科

出　　处：《中华老年医学杂志》1998年第5期311-313,共3页Chinese Journal of Geriatrics

摘　　要：目的观察老年人尿羟脯氨酸（ＨＹＰ）的含量，评估其在老年男性骨质疏松症和糖尿病诊断中的意义。方法采用高效液相色谱法测定２５５例老年人空腹晨尿ＨＹＰ含量，分为健康男性、女性、男性骨质疏松和２型糖尿病患者进行比较，并以３８例青年人做对照。结果老年男性尿ＨＹＰ的含量（１９４．８±７５．４μｍｏｌ／ｇＣｒ）与青年男性差异无显著性（Ｐ＞０．０５）；老年男性中，健康者、骨质疏松症患者及２型糖尿病患者之间差异均无显著性（均为Ｐ＞０．０５）；老年女性（３１５．４±９７．０μｍｏｌ／ｇＣｒ）显著高于老年男性及青年女性组（Ｐ＜０．０１）。结论尿ＨＹＰ作为反映骨胶原快速转换的生化指标。Objective To evaluate the significance of urinary hydroxyproline (HYP) in the diagnosis of osteoporosis and diabetes mellitus in aged. Methods Measurements of urinary HYP were made by using high pressure liquid chromatography in 38 healthy young adults aged 20 39yr as control and 255 old people aged 60 80yr including 38 heatlhy women, 165 heatlhy men, 35 patients with type 2 diabetes mellitus and 17 patients with osteoporosis. The results were expressed as the ratio HYP/creatinine (HYP/Cr). Results There was no significant difference between heatlhy old men (194 8±75 4μmol/g Cr) and young adults ( P >0 05),the old patients with osteoporosis and with diabetes mllitus ( P >0 05). But the mean value of HYP in old women (315 4±97 0μmol/g Cr) was higher than that of old men and young women ( P <0 01). Conclusions The determination of urinary HYP is a biochemical marker of bone turnover in post menopausal women, but is nonspecific for the old male patients with osteoporosis and diabetes mellitus.

关 键 词：羟脯氨酸 尿 骨质疏松 糖尿病 NIDDM 老年人 

分 类 号：R681.04[医药卫生—骨科学] R587.104[医药卫生—外科学]