鲍氏不动杆菌的耐药性分析及临床对策  

Antimicrobial Resistance of Acinetobacter baumannii and Clinical Strategies

作　　者：丁群力[1] 陈华良 邓在春[1] 舒丽华[1] 郎明霞[1] 马红映[1] 虞亦鸣[1] 

机构地区：[1]宁波大学医学院附属医院呼吸科,浙江宁波315020 [2]江北区人民医院呼吸科,浙江宁波315020

出　　处：《中华医院感染学杂志》2009年第19期2644-2646,共3页Chinese Journal of Nosocomiology

摘　　要：目的研究鲍氏不动杆菌的耐药性。方法收集2003年1月-2006年12月医院细菌室分离的鲍氏不动杆菌,采用琼脂扩散法作敏感试验。结果4年共分离鲍氏不动杆菌548株,分布在重症监护病房(ICU)130株(23.7%),外科190株(34.7%),内科168株(30.7%),急诊科60株(10.9%);痰标本分离的鲍氏不动杆菌最多见,占78.5%,其次为伤口分泌物,鲍氏不动杆菌的分离率在4年内逐年增加;鲍氏不动杆菌对多种抗菌药物的耐药率均较高,ICU分离菌株耐药率较普通病房明显增高,除对亚胺培南、环丙沙星敏感率较高外,对其他抗菌药物的耐药率均>50%。结论鲍氏不动杆菌对多种抗菌药物耐药,且以ICU分离株最为明显,应引起高度重视。OBJECTIVE To analyze the antimicrobial resistance of Acinetobacter baumannii. METHODS A. baumannii was collected in our hospital from Jan 2003 to Dec 2006. Antimicrobial susceptibility testing was performed by disk-diffusion method. RESULTS A total of 548 A. baumannii were collected during 4 years. Of these isolates, 130（23.7 %） strains were from intensive care unit （ICU）, 190 strains （34. 7%） from surgical, and others from medical and emergency departments. Most of strains（78.5%） were isolated from sputum, next from wound. The prevalence of A. baumannii was increasing during last 4 years. Results of susceptibility test showed that imipenem was the most active antibiotic against A. baumannii. The resistance rates were high to most antibiotics. Most of the resistant strains was from the ICU and the general ward differentand had significant difference. More than 50% of isolates were resistant to all antimicrobial agents tested except imipenem and ciprofloxacin in ICU. CONCLUSIONS The prevalence of A. baumannii is increasing. A. baumannii isolates show high resistance to multiple antibiotics, especially in ICU.

关 键 词：鲍氏不动杆菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]