术后患者深部真菌感染的调查及病原学分析  

Deep Fungal Infection in Patients:Clinical and Pathogenic Analysis

作　　者：李秀丽[1] 廖万清[2] 杨红[3] 白禹[1] 梁丽萍[1] 

机构地区：[1]上海同济大学附属第十人民医院皮肤科,上海200072 [2]第二军医大学长征医院皮肤科,上海200003 [3]上海同济大学附属第十人民医院检验科,上海200072

出　　处：《中华医院感染学杂志》2009年第19期2662-2664,共3页Chinese Journal of Nosocomiology

摘　　要：目的探讨手术后患者并发深部真菌感染的发病率、来源和病原菌构成情况。方法对2006年7月-2008年6月住院的816例术后并发深部真菌感染患者的临床资料进行回顾性分析。结果术后患者真菌检出率为24.82%;感染的真菌中白色假丝酵母菌占第1位(65.69%),其次热带假丝酵母菌(10.57%);96.45%的患者手术前后应用广谱抗菌药物;感染部位依次为心胸、胃肠道、泌尿道、女性生殖道、血液、骨骼等。结论手术创伤是医院深部真菌感染的重要因素,与多种广谱抗菌药物使用密切相关,对术后患者深部真菌感染应采取积极预防、及时发现和有效治疗。OBJECTIVE To investigate the postoperative morhility of deep fungal infections and the source and composition of the pathogenic fungi. METHODS Clinical data of 816 patients with post-operative deep fungal infections from Jul 2006 to Jun 2008 were reviewed and analyzed retrospectively. RESULTS The detectable rate of post-operative deep fungal infections was 24. 82%, among which Candida albicans was the most common （65.69%）, followed by C. tropicalis（lO. 57%） ;the rate of broad-spectrum antibiotic application in peri-operation was 96.45%; the infection site in the descending order was cardio-thorax, gastrointestinal tract, urinary tract, female reproductive system, blood and skeleton. CONCLUSIONS Operative trauma is an important factor that causes deep fungal infections in hospital, and is closely related to broad-spectrum antibiotic application. Positive prevention, timely diagnosis and effective treatment should be highly emphasized when dealing with post-operative deep fungal infections.

关 键 词：真菌病 假丝酵母菌属 曲霉菌属 毛霉菌属 隐球酵母菌属 

分 类 号：R379[医药卫生—病原生物学]