内皮抑素抑制肿瘤血管生成的数值模拟  

NUMERICAL SIMULATION OF INHIBITORY EFFECTS OF ENDOSTATIN ON TUMOR ANGIOGENESIS

作　　者：赵改平[1] 陈二云[2] 沈力行[1] 郦鸣阳[1] 吴洁[3] 许世雄[3] 丁皓[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海理工大学能源与动力工程学院,上海200093 [3]复旦大学力学与工程科学系,上海200433

出　　处：《力学学报》2009年第5期794-800,共7页Chinese Journal of Theoretical and Applied Mechanics

基　　金：国家自然科学基金(10772051);上海高校选拔培养优秀青年教师科研专项基金(571215);博士科研启动费基金(10D214);上海市自然科学基金(09ZR1422500)资助项目~~

摘　　要：数值模拟抗血管生成药物内皮抑素对肿瘤血管生成的抑制效应.建立内皮抑素作用下肿瘤内外血管生成的二维、三维离散数学模型,模型中考虑内皮抑素的抑制作用、内皮细胞自身的增殖、促血管生成因子TAF和Fibronectin对内皮细胞产生的趋化性和趋触性以及内皮细胞自身扩散引起的随机性运动,数值模拟肿瘤内外微血管网的生成过程.模拟结果表明,抗血管生成药物内皮抑素对肿瘤内外血管生成的速度、成熟度以及血管分支数量均有明显的抑制作用,从而有效地抑制肿瘤新生血管的形成.该模型能够较好地模拟内皮抑素对肿瘤血管内皮细胞迁移与增殖的抑制效应,为临床抗血管生成治疗肿瘤提供有益的信息.The inhibitory effects of anti-angiogenic drug Endostatin on tumor angiogenesis are simulated by adopting 2D and 3D discrete mathematical models, which are used to describe the formation of capillary networks inside and outside the tumor. In the discrete mathematical models, five factors were mainly taken into account the influence of the migration of endothelial cells： （i） proliferation and （ii） random motility Of the endothelial cells; （iii） chemotaxis in response to tumor angiogenic factor （TAF） released by the tumor; （iv） haptotaxis in response to fibronectin gradients in the extracellular matrix, especially the inhibitory action of anti- angiogenic drug Endostatin, and （v） inhibitory effects of Endostatin. Meanwhile, spatiotemporal evolution of 2D and 3D tumor microvascular networks is performed. The simulation results indicate that anti-angiogenic drug Endostatin obviously has the inhibitory effects on the rate of blood vessels growth, the bifurcation amount and the development of the microvascular network inside and outside the tumor. Furthermore, the microvascular networks generated by the present mathematical models have relatively realistic structure and morphology inside and outside the tumor. These results may provide beneficial information for anti-angiogenesis treatment of tumor and further clinical research.

关 键 词：内皮抑素 肿瘤 血管生成 抑制效应 数学模型 

分 类 号：R318.01[医药卫生—生物医学工程] TB115[医药卫生—基础医学]