丹参酚酸肠吸收特性研究  

Features of intestinal absorption of salvianolic acid

作　　者：陈贤春[1] 吴清[2] 李冀湘[1] 石红欣 张玲[4] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学中药学院 [3]北京采瑞医药科技有限公司 [4]山东中医药大学药学院

出　　处：《北京中医药大学学报》2009年第9期633-635,640,共4页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：目的以丹参素钠和原儿茶醛为指标,研究丹参酚酸肠吸收特性。方法建立丹参素钠和原儿茶醛含量测定方法,采用大鼠在体肠吸收法,考察不同吸收部位、药物浓度、介质pH对丹参素钠和原儿茶醛吸收量的影响,考察吸收动力学参数。结果丹参素钠和原儿茶醛在小肠各段均有吸收,无特定吸收部位;在实验所设定的浓度范围内2种成分的吸收量均与浓度呈现出良好的线性关系,没有吸收饱和现象发生;pH值对丹参素钠的肠吸收量没有显著影响,而对原儿茶醛有影响;丹参素钠吸收速率常数Ka 0.3996 h^(-1),T_(1/2)1.734 h,原儿茶醛吸收速率常数Ka 0.4019 h^(-1),T_(1/2) 1.724 h。结论丹参酚酸在肠道中吸收良好,吸收机制为被动扩散。Objection To study the intestinal absorptive features of salvianolic acid taking salvianic acid A sodium and protocatechuic aldehyde as the indexes. Methods The method of intestinal absorption was applied in vivo in rats for establishing a quantitative determination of salvianic acid A sodium and protocatechuic aldehyde. The influences of different absorptive segments of intestines, drug concentrations and pH conditions on the intestinal absorptive volume of salvianic acid A sodium and protocatechuic aldehyde were observed, and the parameter of absorptive dynamics was studied. Results There was no specified absorptive segments of intestines. The absorptive volume had a good linear relationship in the range of test concentration without saturation. The value of pH had no influence on intestinal absorption of salvianic acid A sodium, but had on protocatechuic aldehyde. The absorptive rate constant of salvianic acid A sodium （Ka） was 0. 3996 h^-1 and T1/2 was 1. 734 h, and that of protocatechuic aldehyde, 0.401 9 h^-1 and T1/2, 1. 724 h. Conclusion Salvianolic acid can be absorbed well in the intestines, and the mechanism is that the absorption is in a passive diffusion way.

关 键 词：丹参酚酸 丹参素钠 原儿茶醛 肠吸收特性 

分 类 号：R283.1[医药卫生—中药学]