B型脑利钠肽和Tei指数在高血压早期左心室舒张功能不全诊断中的意义  

Value of BNP and Tei index to diagnosis of early stage of left ventricular diastolic dysfunction in essential hypertensive patients

作　　者：高枫 苏伟 龚少愚 陆曙 刘志华[2] 

机构地区：[1]无锡中医院心内科,无锡214037 [2]苏州大学附属第一医院

出　　处：《中华老年心脑血管病杂志》2009年第10期747-749,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨B型脑利钠肽(BNP)与Tei指数在评价原发性高血压左心室舒张功能不全中的意义。方法选择高血压患者83例,分为高血压伴左心室舒张功能不全组(DHF组,35例),高血压无心力衰竭组(NHF组,48例),另选健康体检者20例作为对照组。化学发光法检测BNP,超声心动图检测各个参数,并计算左心室Tei值。结果DHF组Tei指数、BNP明显高于NHF组和对照组(P<0.01),NHF组Tei指数、BNP也明显高于对照组(P<0.05,P<0.01)。BNP法诊断敏感性、特异性明显好于Tei指数法,差异有统计学意义(P<0.05)。结论BNP和Tei指数均为诊断高血压早期舒张功能不全的敏感指标,且BNP法较Tei指数法更为高效、准确。Objective To explore the value of B-natriuretic peptide（BNP） and Tei index to assess- ing early stage of left ventricular diastolic dysfunction in essential hypertension（EH）. Methods Eighty-three hospitalized patients with EH were divided into two groups. 35 patients with diastolic dysfunction（DHF group）, 48 patients with normal diastolic function（NHF group） , and other 20 healthy volunteers were selected as control group. The plasma BNP level was measured by chemiluminescent immunoassay. At the same time the parameters including left atrial and left ventricular end-diastolic diameter, left ventricular end-systolic diameter, interventricular septal thickness, left ventricular posterior wall thickness, isovolumic contraction time,isovolumic relaxation time and left ventricular ejection fraction were measured,and the value of Tel index was calculated. Results The level of plasma Tel index and BNP value increased significantly in DHF group,compared with the control group and NHF group （P〈0.01）. Similarly, both Tel index and BNP in NHF group were significantly higher than those in control group （P〈 0.05,P 〈0.01）. Comparing these two measures in diagnosis of early diastolic dysfunction,BNP showed significantly advantageous than Tel index in both sensitivity and specificity （P 〈 0.05）. Conclusions Both BNP and Tel index are sensitive indexes for diagnosis of early diastolic dysfunction in EH. BNP may be a biochemical index more effective and accurate than Tel index for diagnosis of early diastolic dysfunction.

关 键 词：高血压 利钠肽 脑 心室功能障碍 左 超声心动描记术 

分 类 号：R544.1[医药卫生—心血管疾病]