水飞蓟果实提取物治疗急慢性乙型肝炎的临床回顾性研究  

Clinic retrospective study on treating acute and chronic hepatitis B with extract of Silybum marianum Gaertn

作　　者：蒋祥虎[1] 黄利华[1] 陆忠华[1] 徐微[1] 张英[1] 李燚光[1] 尹光耀[1] 

机构地区：[1]无锡市传染病医院,无锡214005

出　　处：《中华中医药杂志》2009年第10期1363-1366,共4页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:回顾性研究水飞蓟宾葡甲胺片等对比治疗急性和慢性乙型肝炎效果,探讨相关的临床意义。方法:经肝穿刺肝组织病理诊断明确为急性乙型肝炎41例和慢性乙型肝炎205例住院患者各分为3组:水飞蓟宾葡甲胺片组;肝炎灵组;水飞蓟宾葡甲胺-肝炎灵-甘利欣合用组。治疗前后观察指标为常规肝功能检查,以及住院疗程分析。结果:急性和慢性乙型肝炎常规肝功能组在同组治疗前后比较都有一定程度改善(P<0.05):急性和慢性乙型肝炎各3组的治疗前后比较都无显著差异。急性乙型肝炎3组住院治疗时间基本相似;慢性乙型肝炎第1组住院治疗时间比第2组和第3组要缩短2-4d。结论:水飞蓟宾葡甲胺片对慢性乙型肝炎的疗效比较优越,用药比较单数纯和住院治疗时间较短,这不仅减轻肝脏物质代谢的负担,同时也减轻了病人的经济负担。说明治疗时考虑保护肝脏的代偿功能适量用药是非常重要的。如果能够考虑小方中药促进疏通肝脏微循环,可能会更有利于肝脏功能和肝脏组织结构的恢复。Objective：To conduct a clinical tretrospective study on the effect of Silymarin Meglumine Tab on acute and chronic hepatitis B and to explore the related clinical significance. Methods： 41 cases and 205 cases of hospitalized patients pathologically diagnosed as acute and chronic hepatitis B respectively by liver tissuse puncture were divided into three group： ① Silymarin Meglumine Tab group; ② Ganyanling group; ③ complex group consisting of Silymarin Meglumine Tab and Gangyanling and diammonium glycyrrhizinate. To detect the index of routine liver function test before and after the treatment and analyze the hospitalization treatment course. Results： Compared with before treatment, liver functions of acute and chronic hapatitis B were improved to certain extent within each group after treatment （P0.05）. There was no significant difference among the three group of acute and chronic hepatitis B both before and after the treatmet （P0.05）. The hospitalization treatment time of acute hepatitis B of the three group were almost the same, but the hospitalization treatmeng time of chronic hepatitis B of the Silymarin Meglumine Tab group was 2-4days less than that of the Ganyanling group and the complex group. Conclusion： As far as Silybini Meglumine Tab was concerned, it was better for chronic hepatitis B than acute hepatitis B because it was less complicated to administer the medicine, relieving the liver＇s burden of metabolism, and hospitalization treatment time was shorter, relieving patients＇ financial burden,which suggested that it was important to administer proper amount of medicine while taking into consideration protecting the liver＇s compensation function. If consideration was given to stimulating liver microcirculation with small dosage of TCM, so as to promote the exchange of the liver metabolite in blood, or detoxication and expulsion of toxin, it was likely to be more advantageous to the restoration of liver function and the liver tissue structure.

关 键 词：急性乙型肝炎 慢性乙型肝炎 水飞蓟宾葡甲胺片 适量用药 疏通肝脏微循环 

分 类 号：R259[医药卫生—中西医结合]