三种不同剂量的米非司酮作为紧急避孕药的研究  

A Prospective Randomized Study of Comparing Three Doses of Mifepristone in Emergency Contraception

作　　者：丁菊红[1] 童建孙 朱川华 张晓林[1] 

机构地区：[1]江苏省计划生育研究所,南京210029

出　　处：《生殖与避孕》1998年第5期295-300,共6页Reproduction and Contraception

基　　金：世界卫生组织人类生殖处房事后避孕组资助

摘　　要：本文对三种不同剂量的米非司酮作为紧急避孕药进行了比较研究.240例健康妇女被随机分配在三种剂量组:10mg、50mg和600mg.服药后有1例失败.此例为10mg组,同房与服药时间相距为84.5h.三组恶心与呕吐等副反应发生率基本相似.但对月经周期影响各不相同.剂量越小对月经周期的干扰越小.引起月经延迟(比预计月经迟≥4天),10mg、50mg和600mg三组分别为21例(28.4%),34例(42.5%)及45例(60%),平均延迟时间600mg组为9.8土11.1天,明显大于10mg和50mg组(2.3土0.8天,5.7±11.3天).同时在月经不同时相服药对月经干扰也不一样.在黄体期服药者延迟月经的例数多,天数长.以上结果提示,小剂量的米非司酮10mg与600mg米非司酮一样可以作为紧急避孕药使用,而且副反应小.但如何克服服用米非司酮作为紧急避孕药后月经的延迟仍是一个值得研究的问题.A prospect randomized study of comparing three dose (10,50,600 mg) of mifepristone in emergency contraception is made. Two hundred and forty subjects were recruited from the clinic of our institute for post -coital contraception within 120 h. One pregnancy occurred in the 240 subjects. She was in 10 mg group; coitus and treatment interval was 84. 5 h. No difference in vomiting and fatigue among three groups. The fewer doses were, the less prolonged days than expected were. In 10 mg, 50 mg, 600 mg groups, menstruation which came later(≥4 days later than expected) was 28. 4%, 42. 5% and 60% respectively. The days of delay in the onset of menstruation were 2. 3? days, 5. 7?1. 3 days and 9. 8?1. 1 days. The cases and days of delay in the onset of menstruation were more and longer in women who administrated the drug at the luteal phase. Bleeding within 5 days after administration of mifepristone most occuured in those who administrated in later follicular phase or luteal phase.

关 键 词：剂量 米非司酮 紧急避孕 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]