大鼠肝脏胰腺十二指肠整块联合异位移植  

Simultaneous en bloc liver, pancreas, and duodenum heterotopic transplantation in rats

作　　者：孟令忠[1,2,3] 钟守先[1,2,3] 乔海泉 肖毅[1,2,3] 

机构地区：[1]中国协和医科大学追加训练班 [2]北京协和医院基本外科 [3]哈尔滨医科大学附一院普外科

出　　处：《中华器官移植杂志》1998年第4期211-213,共3页Chinese Journal of Organ Transplantation

摘　　要：为探索肝胰十二指肠整块联合移植（ＳＨＰＤ）术式的可行性，在国内首先建立了大鼠ＳＨＰＤ模型，并评价了术后大鼠生存以及移植物功能状况。结果表明大鼠异位ＳＨＰＤ切实可行，手术成功率高（７６．９％），术后１周存活率达７５％，能长期存活（＞３个月），术后行相关检查，表明移植物血管通畅，供肝和供胰有功能。该模型可用于移植免疫以及肝营养等实验研究，另外该术式对某些良性肝脏疾患伴或不伴Ⅰ型糖尿病的治疗有启发性。In order to study the operation feasibility of heterotopic simultaneous en bloc liver, pancreas, and duodenum transplantation (SHPD), the SHPD model in rats was established for the frist time in China, the status of rat survival and graft function evaluated postoperatively. The results revealed that the rat SHPD model was feasible, with the operative successful rate being 76.9% , oneweek postoperative survival rate being 75%, long survival time without complications being more than 3 months, and good function of the grafted liver and pancreas. In addition, SHPD model is suitable for the experimental study of transplantation immunology, hepatotrophism, etc, and enlightens the treatment of some benign liver diseases with or withour type 1 diabetes mellitus.

关 键 词：肝脏 胰腺 十二指肠 联合移植 异位移植 

分 类 号：R617.05[医药卫生—外科学]