肾移植术后监测环孢素浓度的临床意义  

Clinical implication of cyclosporine concentration determination after renal transplantation

作　　者：姜汉英[1] 廖永芳[1] 余源 张红[1] 程敦秀 夏穗生[1] 

机构地区：[1]同济医科大学同济医院器官移植研究所

出　　处：《中华器官移植杂志》1998年第4期222-223,共2页Chinese Journal of Organ Transplantation

摘　　要：为了进一步探讨环孢素Ａ（ＣｓＡ）理想的治疗窗范围，指导临床合理应用免疫抑制剂，以减少急性排斥反应发生和肝肾毒性反应，对肾移植术后５１０例患者进行了ＣｓＡ血浓度测定，实验结果表明：术后不同时期各组间ＣｓＡ的浓度范围有显著差异（Ｐ＜０．００１），认为监测ＣｓＡ浓度有利于减少急性排斥反应和肝。In order to assess the proper therapy window of Cyclosporine AL (CsA) and direct the clinical administration of anti rejection drug, the levels of blood CsA in 510 patients with reual transplantation were determined. The result showed: that the concentrations were significantly different at the differeat periods of post-transplantation among the groups (P< 0.01 ). It was believed that it's helpful to monitor the CsA blood level in the prevention of the graft rejection and the drug toxicity to the liver and kidney.

关 键 词：肾移植 治疗窗 环孢素 排斥反应 

分 类 号：R699.2[医药卫生—泌尿科学] R392.4[医药卫生—外科学]