金丝桃甙对大鼠脑梗塞的保护作用  

Protective Effect of Hyperin on Cerebral Infarction in Rats

作　　者：陈志武[1] 章家胜[1] 马传庚[1] 

机构地区：[1]安徽医科大学药理教研室

出　　处：《中国中药杂志》1998年第10期626-628,共3页China Journal of Chinese Materia Medica

摘　　要：目的：研究金丝桃甙（Ｈｙｐ）对脑梗塞的保护作用。方法：大鼠脑梗塞模型采用右侧颈总动脉和右侧大脑中动脉结扎，脑梗塞重量用ＮＢＴ染色法测定，取脑皮质测定一氧化氮（ＮＯ）和丙二醛（ＭＤＡ）的含量，大鼠脑皮质血流量（ＣＢＦ）用氢清除法测定。结果：Ｈｙｐ６．２５，１２．５，２５ｍｇ·ｋｇ－１可显著改善大鼠异常神经症状，１２．５，２５ｍｇ·ｋｇ－１减轻脑梗塞重量的抑制脑皮质ＮＯ和ＭＤＡ含量的增高，并增加脑皮质血流量。结论：金丝桃甙对脑梗塞有保护作用。Objective:To study the protective effect of hyperin (Hyp)on cerebral infarction.Method:The cerebral infarction in rats was made by ligating the right common carotid artery and the right middle cerebral artery.The infarction weight was determined by NBT stain .The cerebral cortex was taken to measure nitric oxide (NO)and malondialdehyde (MDA).The cerebral blood flow(CBF)was measured with H 2 clearance method.Result:Hyp 6.25,12.5,25mg·kg -1 markedly improved the abnormal nervous symptoms,and 12.5,25mg·kg -1 Hyp significantly reduced the infarction weight and inhibited the increase of MDA and NO in the cerebral cortex.Hyp(25,12.5mg·kg -1 )could increase the CBF of the cerebral cortex.Conclusion:Hyp has a protective effect on cerebral infarction via attenuating lipid peroxidation and NO.

关 键 词：脑梗塞 金丝桃甙 中医药疗法 药理学 

分 类 号：R285.5[医药卫生—中药学] R277.733.3[医药卫生—中医学]