益肝抗纤方治疗慢性乙型肝炎肝纤维化的临床与实验研究  

Effect of Prescription for Invigorating Liver and Prevent Fibrosis in Treatment of Liver Fibrosis in Chronic Hepatitis B

作　　者：董筠[1,2] 纪钧[1,2] 俞荣青[1,2] 

机构地区：[1]南京中医药大学附属医院 [2]江苏省通州市中医院

出　　处：《南京中医药大学学报》1998年第6期335-338,共4页Journal of Nanjing University of Traditional Chinese Medicine

摘　　要：目的：观察益肝抗纤方治疗慢性乙型肝炎肝纤维化的疗效。方法：慢性乙型病毒性肝炎（中度）辨证属肝郁脾虚、湿热中阻、瘀血阻络或相互兼证者予益肝抗纤方治疗；实验研究以四氯化碳等复合因素致大鼠慢性肝损伤及肝纤维化模型，观察益肝抗纤方２种剂量抗肝纤维化的作用，并以秋水仙碱对照。结果：治疗组５０例，显效率６２．０％，对照组５０例，显效率４０．０％，２组比较，Ｐ＜０．０５。肝功能试验及肝纤维化指标ＰＣⅢ、ＨＡ、ＬＮ在治疗后均有显著性好转。治疗组之肝郁脾虚证、湿热中阻证疗效相仿，显效率分别为７３．９％、６６．７％，瘀血阻络证疗效较差，仅２２．２％，提示后者肝纤维化较重，治疗较难。实验研究结果证实益肝抗纤方有抗肝纤维化作用及剂量依赖性。结论：中药复方益肝抗纤方治疗慢性乙型肝炎（中度）之肝郁脾虚证、湿热中阻证、瘀血阻络证及相互兼证，有抗肝纤维化作用。OBJECTIVE:To observe the effect of the Prescription for invigorating the liver and preventing liver fibrosis in the treatment of liver fibrosis in patients with chronic hepatitis B.METHOD:Animal models were made with rats with liver fibrosis and were then treated with the prescription (large and small dosage),compared with a colchicin control groap.RESULT:In the treatment group of 50 patients the markedly effective rate was 62.0% while in the control group of 50 patients,the rate was 40.0% ( P <0.05).Liver function examination showed that the liver fibrosis indexes such as PCIII,HA,LN improved greatly.The results suggest that the prescription is effective against liver fibrosis and has dosage dependence.CONCLUSION:This compound prescription has the anti-fibrosis function in treating different syndromes of chronic hepatitis B,such as the syndrome of liver depression and sleep deficiency,the syndrome of obstruction by damp heat,the syndrome of obstruction of the channel by blood stasis ,and combination of these syndromes.

关 键 词：乙型肝炎 益肝抗纤方 肝纤维化 中医药疗法 

分 类 号：R259.126.2[医药卫生—中西医结合] R259.752[医药卫生—中医内科学]