贫困农村儿童普服维生素A预防呼吸道感染  

Follow-up study of poor rural children supplemented with vitamin A to prevent respiratory infection

作　　者：房少华[1] 刘锦桃[1] 仇赛云[1] 忽丽莎[1] 

机构地区：[1]云南省妇幼保健院儿童保健科,昆明650051

出　　处：《中国生育健康杂志》2009年第4期207-210,共4页Chinese Journal of Reproductive Health

摘　　要：目的研究补充维生素A与呼吸道疾病间的关系,降低贫困农村5岁以下儿童呼吸道疾病的患病率及死亡率。方法采用典型调查与分层整群抽样的方法,对5岁以下儿童呼吸道感染的患病率进行基线和终末调查,维生素A干预用前瞻性队列研究方法,对资料进行logistic回归及COX回归模型统计学分析。结果急性呼吸道感染患病率服维生素A前为23.9%,服维生素A后为9.0%,相对危险度(RR)为2.7,归因危险度百分比(ARP)为62.0%;反复呼吸道感染患病率服维生素A前为10.0%,服维生素A后为4.7%,RR为2.1,ARP为53.0%。COX回归分析服维生素A后,年龄不再是急性呼吸道感染的危险因素。结论定期补充双剂量维生素A对预防急性呼吸道感染、反复呼吸道感染有明显效果。Objective To examine the relationship between vitamin A supplementation and incidence of respiratory disease, in order to decrease morbidity and mortality from respiratory tract infection among children under 5 years of age in impoverished rural area. Methods A cross-sectional survey and a stratified cluster sampling were used to obtain baseline and end-point information on children under 5 years of age. Children who were supplemented with vitamin A were followed-up. Results The prevalence of acute respiratory infection was 23.9 % before vitamin A supplementation and 9.0 % after supplementation with a relative risk （RR） of 2.7 and attributable risk percent （ARP） of 62.0 %. Recurrent respiratory infection rate was 10. 0 % and 4. 7 % before and after vitamin A supplementation, resulting in a RR of 2. 1 and ARP of 53. 0 %. Age was not an independent risk factor for acute respiratory infection in the COX model. Conclusion Double doses of vitamin A supplement have a protective effect on acute and recurrent respiratory infection among children under 5 years of age in poor rural area.

关 键 词：5岁以下儿童 维生素A 呼吸道疾病 

分 类 号：R179[医药卫生—妇幼卫生保健]