临床深部真菌感染的菌群分布及耐药性调查  

Investigation of distribution of pathogens and drug resistance in clinical deep fungal infections

作　　者：齐桂云[1] 郭微媛[1] 石华[1] 孙琪[1] 徐洪伟[1] 李蓉[2] 

机构地区：[1]哈尔滨医科大学附属第二医院,哈尔滨150086 [2]中国疾病预防控制中心,北京100021

出　　处：《中国卫生检验杂志》2009年第10期2400-2401,共2页Chinese Journal of Health Laboratory Technology

基　　金：黑龙江省自然科学基金资助项目(D200506)

摘　　要：目的：了解我院真菌感染临床分布及耐药性变化，以引起临床广泛关注。方法：念珠菌显色培养基鉴定2008年1—6月期间不同标本中分离的真菌，Rosco纸片扩散法作真菌药敏试验，包括氟康唑、二性霉素B、伊曲康唑和氟胞嘧啶四种抗真菌药物。结果：192株临床真菌中，白色假丝酵母菌为主，主要分布于痰和尿标本中，对四种抗真菌药物的敏感率除伊曲康唑外均超过90％以上。结论：深部真菌感染主要由白色假丝酵母菌、热带假丝酵母菌，光滑假丝酵母菌引起，重视真菌的培养鉴定和药敏试验，指导临床合理选择抗真菌药物。Objective：To investigate the distribution of clinical fungus infection in order to analyze reasons, and causes more attention in clinical practice. Methods： Fungi were isolated by CHROMagar medium between 1 - 6 month in 2008. the fungi resistance to antifungal agents were examined including fluconazole, amphotericin B, itraconazole and flucytosine by Rosco disk diffusion method. Results： 192 strains were identified, Candida albicans was the main species; they are distributed mainly among sputum and urine. All detected fungus show drug susceptibility to 4 antifungal drugs over 90% except itraconazole. Conclusion：Candida aibicans, candidatropicalis and candida glabrata are the main microorganism at clinical fungal infections; antifungal drugs should be applied on the basis of drug susceptibility test to minimize fungus infection caused by the antibiotics, it would be beneficial to the proper clinical use of antibiotics.

关 键 词：深部真菌 医院内感染 调查分析 

分 类 号：R519[医药卫生—内科学] R181.34[医药卫生—临床医学]