暴发性1型糖尿病临床流行病学调查  

Epidemiological investigation of fulminant type 1 diabetes

作　　者：郑超[1] 王臻[1] 张贻宇[1] 谭愈昱[1] 超晨[1] 周海峰[1] 杨亚玲[1] 车志宏[1] 周智广[1] 

机构地区：[1]中南大学湘雅二医院内分泌科、中南大学糖尿病中心、中南大学代谢综合征研究中心、中南大学代谢内分泌研究所,长沙410011

出　　处：《中国糖尿病杂志》2009年第9期646-648,共3页Chinese Journal of Diabetes

基　　金：教育部高校博士点基金(200805330055);湖南省卫生厅重点项目(A2004-004);国家863项目(2006AA02A409)

摘　　要：目的了解住院糖尿病患者中暴发性1型糖尿病的患病状况。方法采用Hanafusa提出的标准诊断暴发性1型糖尿病。系统性回顾2001～2008年本院内分泌科住院糖尿病患者情况,分析暴发性1型糖尿病所占比例。结果 8年间本院内分泌科住院糖尿病患者共8801例,其中新诊断急性起病1型糖尿病患者107例,暴发性1型糖尿病患者为11例。暴发性1型糖尿病约占本院连续住院糖尿病患者的1‰,新发1型糖尿病患者的10%。未观察到暴发性1型糖尿病发病逐年增加及月份聚集现象。结论暴发性1型糖尿病呈散发,成年人中常见,临床中应注意鉴别诊断。Objective To investigate the prevalence of fulminant type 1 diabetes （FID） in Second Xiangya Hospital of Central South University. Methods With the diagnostic criteria proposed by Hanafusa, F1D patients were screened from the admitted diabetic patients in the Second Xiangya Hospital from 2001 to 2008. And their epidemiological features were analyzed. Results Eleven FID patients were found from 8801 consecutive hospitalized diabetics,including 6 male and 5 female patients. F1D accounted for about 1%0 in the consecutive hospitalized diabetics and 10% in newly diagnosed ketosis- or ketoacidosisonset type 1 diabetes in the Second Xiangya Hospital. The average age at onset in fulminant type 1 diabetics were 34± 11 year. No year and month preference were observed. Conclusions The onset of F1D is sporadic, and FID is usally seen in adults.

关 键 词：糖尿病 1型 暴发性 糖尿病酮症酸中毒 流行病学 

分 类 号：R587.1[医药卫生—内分泌] R181.3[医药卫生—内科学]