糖尿病前期人群糖负荷后1小时血糖切点及其与胰岛β细胞功能关系的探讨  

Investigation of cut point of OGTT-1hPG for prediabetes and the relation of 1hPG with the function of β cell

作　　者：李颖[1,2] 刘东方[1] 周厚地[1] 庞久高[1] 邓华聪[3] 

机构地区：[1]重庆医科大学附属第二医院内分泌科,400010 [2]重庆市红十字会医院内科 [3]重庆医科大学附属第一医院内分泌科

出　　处：《中国糖尿病杂志》2009年第9期676-678,共3页Chinese Journal of Diabetes

摘　　要：目的探讨非糖尿病(DM)人群糖负荷后1小时血糖(1hPG)的切点及其与胰岛β细胞功能的关系。方法以OGTT1hPG值为8.0mmol/L和10.5mmol/L为界将非DM人群分为三组,比较各组胰岛β细胞功能和相关指标。结果 (1)1hPG>8.0mmol/L时,HOMA-β、△I/△G、30min Ins和AUC_(30Ins)低于1hPG<8.0mmol/L组(P<0.05或P<0.01),HOMA-IR高于1hPG<8.0mmol/L组(P<0.05);(2)1hPG>10.5mmol/L时胰岛β细胞功能和相关指标改变更明显。结论 1hPG>8.0mmol/L时有胰岛β细胞功能改变、早相胰岛素分泌减少及外周胰岛素抵抗存在,1hPG>10.5mmol/L时这些改变更明显。推测8.0mmol/L可能为1hPG的切点。Objective To investigate the cut point of OGTT-one hour plasma glucose（lhPG） for prediabetes and the relationship of lhPG with the function ofβ cell. Methods Patients with prediabetes were divided into three groups of A： 1hPG 〈 8.0 ; B： 8.0 〈 1 hPG〈 10. 5 ; C ： 1 hPG〉10. 5mmol/L. The function of beta cell and correlated index were compared. Results HOMA-β, △I/△G, 30min Ins and AUC301nswere lower in B and C group than in A group （P〈0. 05 or P〈0.01）, HOMA-IR were higher in B and C than in A group（P〈0.05）. The changes of function of beta cell and the correlated index were more obvious in C group. Conclusions The early phase insulin secretion is decreased with insulin resistance increase when lhPG exceeds 8.0mmol/L. These changes are obvious when lhPG exceeds 10.5mmol/L. So we presume 8. 0mmol/L may be the cut point of lhPG for prediabetes.

关 键 词：负荷后1小时血糖 切点 胰岛Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌] R973[医药卫生—内科学]