核-壳型厚朴酚印迹聚合物的制备及性能研究  

Synthesis and Evaluation of Core-Shell Molecularly Imprinted Polymers for the Selective Recognition of Magnolol

作　　者：刘丽[1] 张朝晖[1,2] 聂丽华[2] 

机构地区：[1]吉首大学化学化工学院,湖南吉首416000 [2]湖南大学化学生物传感与计量国家重点实验室,长沙410082

出　　处：《化学通报》2009年第10期907-911,共5页Chemistry

基　　金：湖南省自然科学基金项目(08JJ4004);湖南省教育厅优秀青年基金项目(07B061);湖南大学化学生物传感与计量国家重点实验室开放基金;吉首大学校级课题(08JDY020)资助

摘　　要：以表面修饰功能基团的SiO2微球为基体,以厚朴酚为模板分子,丙烯酰胺为功能单体,丙烯酸乙二醇二甲酯为交联剂,在SiO2微球表面制备对厚朴酚具有较好选择识别能力的核-壳型印迹聚合物。采用红外光谱及扫描电镜等技术表征聚合物的结构及形态。结果表明,该印迹聚合物表面成功制备了壳层厚度约为200nm的均匀印迹层。通过静态吸附、Scatchard分析法以及竞争吸附实验研究了该聚合物的吸附性能和选择性,结果表明,它对厚朴酚形成均一结合位点,离解常数为0.19mg/mL。Core-shell molecularly imprinted polymers （MIPs） for the selective recognition of magnolol were prepared based on SiO2 microspheres by surface imprinting polymerization using magnolol as template molecule. Equilibrium binding experiment,Scatchard analysis and competition binding experiments were conducted to investigate the binding performance and selectivity. The results showed that a homogeneous binging site was observed for the imprinted polymers binding to the template with the dissociation constant 0.19mg/mL. IR and scanning electron microscopy technique were also employed to characterize the core-shell imprinted polymers. The results exhibited that the core-shell imprinted polymers have perfect spherical shape with the average shell thickness of 200nm. The MIPs-column exhibited excellent selectivity to magnolol with the selective factor 1.62.

关 键 词：核-壳型 厚朴酚 分子印迹 性能 

分 类 号：O631.3[理学—高分子化学]