牛奶、母乳中全氟化合物分析方法的研究  

Determination of 12 perfluorinated compounds in milk products

作　　者：王杰明[1] 潘媛媛[1] 史亚利[1] 蔡亚岐[1] 

机构地区：[1]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085

出　　处：《分析试验室》2009年第10期33-37,共5页Chinese Journal of Analysis Laboratory

基　　金：国家高新技术研究计划(2007AA06Z405);中国科学院重要方向性项目(KZCX2-YW-420-1);国家自然科学基金创新群体(20621703)项目资助

摘　　要：建立了HPLC-ESI-MS/MS联用技术测定奶制品中12种全氟化合物（PFCs）的方法。12种全氟化合物包括9种常见PFCs和2种调聚酸及一种全氟磺酰胺。对比了MTBE液-液萃取、甲酸、乙腈和甲醇萃取这4种萃取方法对12种全氟化合物的萃取和回收效果。最终选用甲醇作为萃取溶剂,并选取WAX作为固相萃取柱对萃取的溶液进行净化,方法对12种PFCs的加标回收在83.5%-113.3%之间,检出限0.005-0.092μg/L。最后完成了对纯牛奶,早餐奶和母乳样品中12种PFCs的分析。A method has been established for the determination of 12 perfluorinated compounds（PFCs） including PFHxS,PFHpA,PFOA,PFOS,PFNA,PFDA,PFUnDA,PFDoDA,PFTA,POEA,FOUEA and FOSA in milk products with high performance liquid chromatography/electrospray tandem mass spectrometry（HPLC-ESI-MS/MS）.The extraction efficiencies of four kinds of solvents were studied,including MTBE,formic acid,acetonitrile and methanol.Methanol was selected as the best one.Under the optimal conditions,the recoveries of PFCs in milk were in the range of 83.5 % - 113.3 % with RSDs of （n = 4） 2.1% -9.7 %. The method detection limit for the real samples ranged from 0. 005 to 0.092 μg/L. Finally, the method was applied to the analysis of PFCs in pure milk, breakfast milk and breast milk.

关 键 词：全氟化合物 牛奶 母乳 高效液相色谱-串联质谱 

分 类 号：O657.7[理学—分析化学]