斑马鱼作为模式生物在心血管疾病研究中的应用  

The application of zebrafish as a model organism in the research of cardiovascular diseases

作　　者：何秋霞[1] 刘可春[1] 楚杰[1] 王思锋[1] 韩利文[1] 王希敏[1] 

机构地区：[1]山东省科学院生物研究所山东省科学院药物筛选研发平台,济南250014

出　　处：《生命的化学》2009年第5期721-726,共6页Chemistry of Life

基　　金：山东省科技攻关项目(2006GG3202038);山东省科学院博士基金项目(科基合字2008第29号)资助

摘　　要：斑马鱼已成为继小鼠之后的又一个重要的模式脊椎动物。斑马鱼的体外发育模式,允许研究人员在发育的各个时期对发育过程进行干预。斑马鱼胚胎和仔鱼的透明特性,使实时观察疾病的发生和发展成为可能。本文将重点介绍斑马鱼在心血管疾病研究中的应用。首先,总结了在以往的研究中,利用斑马鱼这种生物模型在血栓、动脉血管形成、炎症、心肌病、心脏再生和先天性心血管疾病等研究中的应用,然后描述了其在治疗心血管疾病的药物筛选中的应用。最后,对斑马鱼和其他心血管疾病模型进行了比较。Zebrafish has become another important vertebrate animal model in addition to mice. External development of zebrafish allows for interference at any developmental stage. Furthermore, the optical clarity of embryos and larvae allows realtime imaging of developing pathologies. In this review, we focus on modeling cardiovascular diseases in zebrafish. Firstly, we summarize previous studies with the use of this organism to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, cardiac regeneration and congenital heart diseases. Secondly, we evaluate its promise for novel drug discovery. Finally, we consider where the zebrafish fits into the framework of existing cardiovascular models.

关 键 词：斑马鱼 心血管疾病 药物筛选 

分 类 号：R54[医药卫生—心血管疾病]