随机单等位基因的广泛表达  

Widespread random monoallelic expression

作　　者：朱水山[1] 王振杰[1] 张吉翔[1] 

机构地区：[1]南昌大学第二附属医院消化内科,江西省分子医学重点实验室,南昌330006

出　　处：《生命的化学》2009年第5期743-745,共3页Chemistry of Life

基　　金：国家自然科学基金(30160032)资助

摘　　要：不同基因的表达会产生不同表型,然而在相同环境背景下具有同一遗传基因的个体表型也具有明显的差异性。最近研究证实人类常染色体基因具有广泛的随机单等位基因表达现象,表明基因表达具有不确定性。这也许可以解释为什么同一遗传基因的个体对疾病的易感性和对药物的反应存在明显差异性。此类基因表达与某些人类疾病相关。Different gene expression can create various phenotypes, however, genetically identical organisms exhibit remarkable variation in phenotype even when they have identical histories of environmental exposure. Recent works have showed that autosomal genes have widespread random monoallelic expression, suggesting that gene expression is mosaic. It could explain why the genetically identical organisms show notable variability in disease susceptibility and response to medical treatments. This type of gene exprssion is related to some human diseases.

关 键 词：单等位基因表达 随机表达 表型 

分 类 号：Q75[生物学—分子生物学]