慢性肾脏病不同分期血尿酸的变化及其影响因素分析  

Cross-sectional study of serum uric acid level in patients with chronic kidney disease and its influence factors

作　　者：刘迅[1] 唐骅[1] 彭晖[1] 石成钢[1] 陈珠江[1] 娄探奇[1] 

机构地区：[1]中山大学附属第三医院肾内科,广州510630

出　　处：《中国综合临床》2009年第10期1048-1050,共3页Clinical Medicine of China

摘　　要：目的单中心横断面调查慢性肾脏病（CKD）患者血尿酸（uA）水平的基础状况。方法对我院肾内科门诊就诊的CKD患者进行为期9个月的前瞻性横断面调查。结果共有713例CKD患者入选。前3位CKD的病因分别为原发性肾小球疾病（61．2％，436／713）、高血压肾病（7．2％，51／713）和糖尿病肾病（5，8％，41／713）。随着CKD分期的进展，UA水平（F=73．569，P=0．000）和高尿酸血症的发生率（χ2=138．156，P=0．000）显著上升。多元回归分析结果显示，UA水平和GFR呈显著负相关（RR=-1．045。P=0．000），UA水平和DBP、尿蛋白、吸烟、BMI呈显著正相关（RR分别为1．400、15．149、37．696和3．421，P均〈0．05）。结论针对CKD患者UA水平进行单中心横断面调查，有助于确定CKD患者UA水平的变化规律，为进一步综合防治CKD及其心血管并发症奠定基础。Objective To present the baseline characteristics of serum uric acid level in patients with chronic kidney disease（CKD）. Methods A cross-sectional study on CKD patients was carried out in our hospital for 9 months. Results 713 patients were enrolled. The top three causes of CKD in these patients were primary glomerular disease（61.2% , 436/713 ） , essential hypertensive kidney disease （ 7. 2% , 51/713 ） and diabetic nephropathy （5.8% ,41/713）. Serum uric acid level and the incidence of hyperurieemia were associated with the stage of CKD （ F = 73. 569, P = 0.000;χ2 = 138. 156,P = 0.000）. A significantly negative correlation was discovered between serum uric acid level and the level of glomerular filtration rate （RR =- 1. 045,P = 0. 000 ）. A significantly positive correlation of serum uric acid level was found with diastolic blood pressure, proteinuia level, smoking and BMI （ RR = 1.400,15.149,37.696,and 3.421,P〈0.05,respectively）. Conclusions The cross-sectional study of serum uric acid level in patients with CKD will help to determine the dynamic changes of serum uric acid level in Chinese CKD patients and lay a solid basis for the prevention and treatment of CKD and its complications.

关 键 词：慢性肾脏病 血尿酸 肾小球滤过率 横断面研究 

分 类 号：R692[医药卫生—泌尿科学] R544.1[医药卫生—外科学]