初发糖尿病患者胰岛素强化治疗后胰岛B细胞早期分泌功能恢复与体重变化的关系  

The relation of early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient and body weight changes following intensification therapy of insulin

作　　者：杨历新[1] 张亚萍[2] 米娜[1] 王叶[1] 朱沁芳[1] 韩维良[1] 李金娟[1] 

机构地区：[1]青海省人民医院内分泌科,西宁810007 [2]青海省人民医院心血管高血压科,西宁810007

出　　处：《中国综合临床》2009年第10期1061-1063,共3页Clinical Medicine of China

摘　　要：目的探讨初发糖尿病病患者胰岛B细胞早期分泌功能变化与最大体重下降的关系。方法初发糖尿病患者237例，按照最大体重下降幅度随机分组为1kg以下组、1-5kg组、5妇以上组。治疗前记录前期最大体重及腰围，目前体重及腰围，行标准OGTI＂试验，同时测空腹和餐后30rain血糖、胰岛素及C-肽水平和血压等。并计算胰岛素抵抗指数（HOMA-IR）、早期胰岛素分泌指数（A130／AG30）的变化。应用胰岛素泵强化治疗14d后，复查上述各项指标。结果B细胞早期分泌时相在体重减轻5kg以上组恢复最差，1kg以下组治疗后胰岛索分泌量较1～5kg组和5kg以上组分别增加1．12倍和1．86倍。结论初发糖尿病最大体重下降幅度与胰岛素强化治疗前后B细胞早期分泌功能和恢复程度相关。Objective To explore the relation of early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient and the changes of body weight following intensification therapy of insulin. Methods 237 newly diagnosed type 2 diabetic patients were divided into 1 kg lower group,the 1-5 kg group,the 5 kg above group. The maximum body weight and waist circumference were recorded. The present body weight and waist circumference were measured according to OGTT study,meanwhile,30 minuets blood sugars ,the insulin and the C-peptide （C-P） level and the blood pressure（BP） and the insulin resistance index （HOMA-IR） ,the early insulin secretion index （AI30/AG30） was calculated. All cases were treated for 14 days. Results Early time secretion function of Beta cell in the group keeping above lose weight 5 kg was the worst, after treatment insulin secretion level were increased 1.12 times and 1.86 times in 1 kg lower group than in the 1-5 kg group and above 5 kg group, Conclusions Early time secretion function of Beta cell in newly diagnosed type 2 diabetic patient is correlated with the maximum body weight decrease.

关 键 词：糖尿病 胰岛素 B细胞功能 

分 类 号：R587.1[医药卫生—内分泌] R575.210.2[医药卫生—内科学]