复方丹参注射液对室性心律失常心内膜单相动作电位的影响  

Effect of Compound Salvia Injection on The Monophasic Action Potential of Endocardium in Ventricular Arrhythmia

作　　者：刘希秀[1] 肖业伟[1] 冯志强[1] 盘强文[1] 

机构地区：[1]泸州医学院生理教研室,四川泸州646000

出　　处：《四川解剖学杂志》2009年第3期1-2,5,共3页Sichuan Journal of Anatomy

基　　金：四川省教育厅青年基金项目060201038观察心内膜电活动与心律失常的关系

摘　　要：目的观察丹参注射液对室性心律失常时兔心内膜单相动作电位(MAP)变化的影响,初步探讨其抗心肌缺血致心律失常的作用机制。方法20只家兔随机分为丹参组和对照组,丹参组在心肌缺血造模前静脉注射10ml复方丹参注射液(3 g/kg),对照组注射等容积的生理盐水,每日1次,连续12 d,于第13 d行室性心律失常造模;在造模前后分别检测、记录各项观察指标。结果造模前丹参组平均心率高于对照组,最大除极速度(Vmax)低于对照组(P<0.05),MAP振幅(MAPA)、单相动作电位时程(APD90)与对照组无差别。造模后,20只实验兔均出现心律失常,对照组平均心率、MAPA和Vmax降低,APD90增加(P<0.05);丹参组平均心率、MAPA降低(P<0.05),Vmax与APD90无变化。丹参组在造模后,平均心率高于对照组,APD90低于对照组(P<0.05);Vmax与MAPA在造模后的两组无明显差别。结论丹参能提高心内膜心肌缺血耐受的能力,起到了ATP敏感性钾通道开放剂效应。Objective To explore effect of compound salvia injection on the monophasic action potential of endocardium in ventricular arrhythmia. Methods 20 rabbits were randomized into drug group and control group. The rabbits of drug group were intravenously injected compound salvia（3 g/kg） 10 ml once a day for 12 days before myocardial ischemia, those of control group were given the same volume normal saline. The related observation indexes were recorded and analyzed at pre- and post the arrhythmia modle operation. Results The average heart rate of drug group was higher than that in control group, but its Vmax was lower than that in control group （P 〈 0. 05） . All the rabbits showed arrhythmia after operation, the average heart rate, the action potential amplitude （MAPA） and the Vmax decreased in control group, but the monophasic action potential duration （APD90） increased （P 〈 0.05） ; In the drug group, the average heart rate and the MAPA dereased （P 〈 0.05） , furthermore, its average heart rate was higher than that in control group, but its APD90 was lower （P 〈 0.05） . Conclusion The compound salvia injection can improve the ability of the endomyocardial ischemic tolerance and promote the ATP-sensitive potassium channel opener.

关 键 词：丹参 室性心律失常 心内膜 单相动作电位 

分 类 号：R259[医药卫生—中西医结合]