地黄提取物对阿霉素肾病大鼠的肾脏保护作用  

The Protective Effect of Rehmannia glutinosa Libosch Extract on kidney of Adriamycin Nephrotic Rats

作　　者：陈敏广[1] 林瑞霞[1] 杨青[1] 李广波[1] 唐雪栋[1] 

机构地区：[1]温州医学院附属育英儿童医院肾内科,浙江温州325027

出　　处：《中华中医药学刊》2009年第10期2114-2116,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省教育厅基金资助项目(20051087)

摘　　要：目的:探讨地黄提取物对阿霉素肾病大鼠的保护作用及其作用机制。方法:尾静脉注射阿霉素诱导建立阿霉素肾病大鼠模型,并随机分为对照组(C组)、阿霉素肾病模型组(M组)、地黄提取物治疗组(D组),治疗8周后观察各组尿蛋白、尿素氮、血肌酐及肾脏病理改变;比较各组肾组织纤维连接蛋白(FN)的表达水平。结果:D组各项指标与模型组相比均有统计学差异,形态学观察也显示其肾脏损害轻于模型组。与M组相比,C组及D组肾组织FN表达水平显著下降(P<0.05)。结论:地黄提取物对阿霉素肾病大鼠肾脏有一定的保护作用,其机制至少部分与下调肾组织FN的表达,抑制肾小球系膜过度增殖有关。Objective： To investigate the protective effect and mechanism of rehmannia glutinosa libosch extract on kidney in adriamyein nephrotic rats. Methods ： The rats model of IgA nephropathy was established by tail vein in jection of adriamyc. The adriamycin nephrotic rats were divided randomly into the normal group（ C group） ,the model control group（ M group） and the Dihuang group（ D group）. 24h urinary protein excretion, albumin, serum creatinine, BUN and pathological changes of kidney were examined and the expression levels of kidney fibronectin （ FN ） were determined after 8 weeks treatment. Results： After treatment, all the parameters between the D group and M group were significantly different respectively ; 于 pathological changes in the D group were milder than those in the M group. Compared with M group, the levels of kidney FN were significantly decreased in C group and D group（P 〈0.05）. Conclusion： Rehmannia glutinosa libosch extract can prevents against renal injury in the rats with nephropathy partially by downregulation the renal level of FN and repress the excessive proliferation of mesangial.

关 键 词：地黄提取物 阿霉素肾病大鼠 肾纤维化 纤维连接蛋白 

分 类 号：R285.5[医药卫生—中药学]