雷公藤联合前列腺素E1治疗下肢动脉硬化闭塞症36例临床分析  

Clinical analysis of tripterygium wilfordii combined prostaglandin E1 in treatment of arteriosclerosis obliterans in lower extremity (report of 36 cases)

作　　者：刘明强[1] 郑江华[2] 陈开[2] 

机构地区：[1]犍为县中医院普通外科,四川犍为614400 [2]川北医学院附属医院血管外科,四川南充637000

出　　处：《局解手术学杂志》2009年第5期314-315,共2页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨雷公藤联合前列腺素E1(PGE1)治疗下肢动脉硬化闭塞症(LEAOD)的疗效。方法选取下肢动脉硬化闭塞症患者72例,随机分为对照组36例和治疗组36例,对照组采用单纯前列腺素E1治疗2个疗程,治疗组采用雷公藤联合前列腺素E1治疗2个疗程,比较两组疗效。结果治疗组总有效率91.67%,对照组总有效率72.22%,差异有统计学意义(P<0.01)。结论雷公藤联合前列腺素E1治疗下肢动脉硬化闭塞症较单纯前列腺素E1疗效好,而且药源丰富易取,价格低廉,值得进一步深入研究。Objective To evaluate the therapeutic effect of tripterygium wilfordii combined prostaglandin El （ PGE1 ） in treatment of arteriosclerosis obliterans（ASO） in lower extremity. Methods Totally 72 patients with ASO were randomly divided into the treatment group （36 cases） and the control group（36 cases）. The treatment group had been treated with tripterygium wilfordii combined PGE1 for 2 courses of treatment. The control group had been treated only with PGE1 for 2 courses of treatment. Therapeutic effect was compared. Results The total effective rate of the treatment group and the control group is 91.67% and 72.22% respectively. Two groups had significant differnee （ P 〈 0. 01 ）. Conclusion The therapeutic effect of tripterygium wilfordii combined PGE1 is superior to that of the PGE1 only in treatment of ASO in lower extremity. Further study should be carried out for its low price and abundant medicinal herbs.

关 键 词：下肢动脉硬化闭塞症 雷公藤 前列腺素E1 

分 类 号：R543.5[医药卫生—心血管疾病]