基于鹿特丹标准诊断的多囊卵巢综合征患者月经类型及其意义  

Different types of menstrual cycle and their significance in Chinese women diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria

作　　者：徐兴华[1] 谭迎春[2] 石玉华[1] 王斌[3] 鞠秀清[4] 郑庆梅[5] 郝翠芳[6] 陈子江[1] 

机构地区：[1]山东大学附属省立医院生殖医学中心山东省生殖医学重点实验室,济南250021 [2]山东大学附属千佛山医院 [3]山东省聊城市人民医院 [4]山东省滕州市中心人民医院 [5]青岛大学医学院 [6]烟台毓璜顶医院

出　　处：《中华医学杂志》2009年第37期2604-2606,共3页National Medical Journal of China

基　　金：山东省自然科学基金（Z2002C05）;国家“973”项目（2007CB948103）;国家自然科学基金（30670777）志谢 北京协和医院妇产科张以文教授在本研究和论文撰写中予以指导

摘　　要：目的分析基于鹿特丹标准诊断的中国人多囊卵巢综合征（PCOS）患者不同月经类型的临床资料及内分泌代谢指标，以指导临床治疗。方法将符合鹿特丹标准的2100例PCOS患者按闭经、月经稀发、月经规律进行分组，分别进行代谢及内分泌等指标的比较。结果（1）闭经组多毛、多囊卵巢发生率均高于月经稀发组（P〈0．01）。（2）闭经组的血清睾酮最高，月经稀发组最低（P〈0．01）；黄体生成素（LH）在闭经组最高（P〈0．01），在月经稀发组和月经规律组间差异无统计学意义（P〉0．05）；黄体生成素／卵泡刺激素（LH／FSH）在月经规律组增高明显（P〈0．01）。（3）口服葡萄糖后2h血糖在闭经组显著增高（P〈0．01）。结论符合鹿特丹标准的不同月经类型的PCOS患者具有不同的临床表现及代谢、内分泌特点，对于不同月经类型PCOS患者的治疗也应该个体化。Objective To analyze the clinical and metabolic characteristics of Chinese women with different menstrual types. All the women were diagnosed with polycystic ovary syndrome according to the Rotterdam consensus criteria. Methods A total of 2100 patients were divided into three groups： amenorrhea, oligomenorrhea and regular menstruation. The metabolism and endocrine indices were determined and compared among three groups. Results （ 1 ） The incidences of hirsutism and PCO were obviously higher in the amenorrhea group than in the oligomenorrhea group （ P 〈 0. 01 ）. （ 2 ） The amenorrhea group had the highest level of serum testosterone while the oligomenorrhea group had the lowest. Moreover, the level of luteinizing hormone （LH） was higher in the amenorrhea group than in the other two groups （P 〈 0.01 ）. However the ratio of LH/FSH increased significantly in the regular menstruation group （P 〈0.01 ）. （3） The value of 2 h blood glucose was the highest in the amenorrhea group （P 〈 0.01 ）. Conclusion PCOS patients with diverse types of menstrual cycle show different clinical manifestations and metabolic and endocrine characteristics so that the choice of treatment should be individualized.

关 键 词：多囊卵巢综合征 月经 

分 类 号：R686[医药卫生—骨科学]