人工晶状体基体材料聚丙烯酸酯水凝胶的制备及性能  

Preparation and Properties of Poly(acrylic ester) Hydrogel as Basic Materials for Intraocular Lens

作　　者：夏宇正[1] 刘辉[1] 石淑先[1] 陈晓农[1] 焦书科[1] 

机构地区：[1]北京化工大学材料科学与工程学院新型高分子材料制备与加工北京市重点实验室,北京100029

出　　处：《生物医学工程学杂志》2009年第5期1047-1051,共5页Journal of Biomedical Engineering

摘　　要：聚丙烯酸酯水凝胶因其优异的光学性能和生物相容性而广泛用作人工晶状体及隐形眼镜材料。我们研究了亲水性单体甲基丙烯酸羟乙酯与疏水性单体甲基丙烯酸甲酯的本体共聚行为,并考察了不同单体配比的聚合物及其水凝胶的光学性能、钙盐沉积、平衡含水量等规律。结果表明,随亲水性单体含量从0增至100%时,所得水凝胶的平均透光率和平衡含水量增大,邵氏A硬度减小,其中平均透光率最高达97%,邵氏A硬度从92降至25,平衡含水量从16%升至64%,且交联单体的加入降低了水凝胶的吸水能力。亲水性单体与疏水性单体质量比为90∶10时,所得聚合物及其水凝胶综合性能最优。Poly（acrylic ester） hydrogel materials were widely used in intraocular lens and contact lens because of their excellent optical performance and biocompatibility. In this paper, the bulk copolymerization behavior of hydrophilic hydroxyethyl methacrylat with hydrophobic methyl metharylate was studied;and the optical performance, calcium deposits,equilibrium water content of polymers and its hydrogels obtained by different ratios of monomers were systematically investigated. The experimental results showed that the average light transmittance and the equilibrium water content of the obtained hydrogels increased with the increasing of the hydrophilic monomer content from 0 to 100%; however, the hardness decreased. The highest light transmittance reached 97% and the hardness of Shore A fell from 92 to 25, the equilibrium water content of hydrogel increased from 16 % to 64%. The absorbent capacity of copolymers reduced with the adding of cross-linking monomer. When m（hydrophilic monomer） ： m（hydrophobic monomer） = 90： 10, the combination property of the polymer and its hydrogel obtained is optimum.

关 键 词：水凝胶 聚丙烯酸酯 人工晶状体 光学性能 

分 类 号：R318.08[医药卫生—生物医学工程]