超声空化空泡用作基因或药物载体研究中的几个关键问题  

Key Problems in Using Ultrasonic Cavitating Bubble as a Gene or Drug Vector

作　　者：张祎伟[1] 陈铁军[1] 刘树红[1] 

机构地区：[1]清华大学水沙科学与水利水电工程国家重点实验室,北京100084

出　　处：《生物医学工程学杂志》2009年第5期1129-1132,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(50746022);北京自然科学基金资助项目(3073020)

摘　　要：超声在液体中作为一个振荡源诱发空化,产生的空泡因其独特的性质可作为基因输送和药物靶向传输的载体。本文就空化机制、声致穿孔控制和超声造影剂的影响三个方面展开论述,探讨了上述问题的研究现状与面临的挑战,旨在为超声空化空泡作为载体的临床应用研究提供文献支持。Ultrasound, serveing as an oscillating source, can induce cavitation in liquids; and the bubble produced in this process is a very promising kind of vector for gene delivery and drug target release, owing to its unique properties. This article involves the cavitation mechanism, the control over sonoporation, and the influence of ultrasound contrast agent. The status quo of research and the challenges encountered are discussed. This overview is devoted to providing a theoretical basis for clinical use of cavitating bubble vector.

关 键 词：超声空化空泡 载体 空化机制 声致穿孔超声造影剂 

分 类 号：R346[医药卫生—基础医学]