生物材料血液相容性的研究与评价  

Study and Evaluation on Hemocompatibility of Biomaterials

作　　者：杨立峰[1,2] 许建霞[3] 奚廷斐[1,3] 

机构地区：[1]温州医学院,温州325035 [2]广东省医疗器械质量监督检验所,广州510080 [3]中国药品生物制品检定所,北京100050

出　　处：《生物医学工程学杂志》2009年第5期1162-1166,共5页Journal of Biomedical Engineering

摘　　要：血液相容性是生物相容性的一个重要组成部分。材料血液相容性的好坏反映了材料与血液相互作用的程度,它们之间的作用是多方面的,其作用机制也非常复杂。本文从接触活化、血浆蛋白的吸附、血小板的激活、凝血酶的产生、补体系统激活、白细胞的活化和溶血等方面阐述了材料对血液的作用,并介绍了目前的评价方法和以后的发展趋势。Hemocompatibility is an important component of biocompatibility; it reflects the degree of interaction between material and blood. Hemocompatibility is multifaeeted, so that the material＇s impact on the blood and the underlying mechanism are very complicated. This article presents a review of researches probing the impact of material on blood via contact activation and plasma protein adsorption; via the platelet aetivated and the formation of thrombin; via the complement system activated and the activation of leukocytes as well as other mechanisms of hemolysis. The current methods for evaluation and the future trend of development are also introduced.

关 键 词：血液相容性 接触活化 血小板激活 白细胞活化 

分 类 号：R318.08[医药卫生—生物医学工程]