TGF-α和P63在尖锐湿疣组织中的检测  

Detection and Significance of TGF-α and P63 in Condyloma Acuminatum

作　　者：张嫦娥[1] 谭超[2] 马树斌[1] 李文竹[1] 

机构地区：[1]兰州大学第二医院皮肤科,甘肃兰州730030 [2]雅安职业技术学院附属医院皮肤科,四川雅安625000

出　　处：《中国皮肤性病学杂志》2009年第10期649-651,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨转化生长因子-α(TGF-α)和P63在尖锐湿疣(CA)发病机制中的作用。方法用PCR技术对34例男性CA组织进行检测;将HPV6/11型感染的CA组织和正常包皮组织15例应用免疫组化(SP法)检测。结果CA标本中26例HPV6/11型感染,阳性率为76.47%;CA组织中TGF-α和P63阳性表达率均为92.31%。TGF-α和P63的表达强度在CA和正常包皮组织中差异均有显著性意义(P<0.01);TGF-α和P63间有相关性(rs=0.003,P<0.01)。结论CA感染中以HPV6/11型占多数,TGF-α和P63在CA发病中起一定作用。Objective To approach the roles of TGF-α and P63 in pathogenesis of condyloma acuminatum（CA）. Methods PCR used to detect the infection of HPV 6/11 type in 34 male cases with CA ; Immunohistochemitry tested the expressions of TGF-α and P63 both in CA with HPV 6/11 type and in normal prepuce of 15 cases. Results There were 26 positive specimens with HPV 6/11 type in 34 lesion ones, the detection rate was 76.47% （26/34） ; The positive rates of both TGF-α and P63 were 92.31% （24/26）. There were statistical differences in the detections of both TGF-α and P63 in CA ; Speaiman related analysis between TGF-α and P63 was correlation （rs = 0. 003, P 〈 0.01 ）. Conclusions The infection of HPV 6/11 type accounts for majority in CA ; And TGF-α and P63 play certain role in the development of CA.

关 键 词：尖锐湿疣 人乳头瘤病毒 P63 转化生长因子-Α 

分 类 号：R392.12[医药卫生—免疫学] R752.53[医药卫生—基础医学]