苯并咪唑大环四胺金属配合物的超分子识别与催化水解作用  

Catalytic hydrolysis and supramolecular recognition by benimidazoly macrocyclic polyamine Zn(Ⅱ) complex

作　　者：李硕[1,2] 向清祥[1] 陈稼轩[1] 周成合[2] 

机构地区：[1]乐山师范学院化学与生命科学学院,四川乐山614004 [2]西南大学化学化工学院,重庆400715

出　　处：《化学研究与应用》2009年第10期1375-1380,共6页Chemical Research and Application

基　　金：四川省科技厅应用基础项目(04JY029-018)资助;四川高校重点实验室专项(2006ZD049)资助;乐山市重点科技计划项目(06GZD043)资助

摘　　要：以1,4,7,10-四氮杂环十二烷(Cyclen)为原料合成了一种新型苯并咪唑大环四胺Zn(Ⅱ)配合物,目标化合物经1HNMR,质谱,元素分析等表征。用紫外光谱法研究了配合物对核苷等的超分子识别作用和对α-吡啶甲酸对硝基苯酚酯(PNPP)的催化水解作用。结果表明配合物与核苷等客体以1∶1或1∶2形式形成超分子化合物,其中对脱氧鸟嘌呤核苷(2’-Deoxyguanosine,dG)的识别作用最强(K=31917 dm3.mol-1);对PNPP的催化水解是其在自然条件下水解速率的25倍。A novel benimidazoly macrocyclic polyamine Zn （ Ⅱ ） complex derived from 1,4,7,10-tetraazaeyclododecane had been synthesized in this paper, the structure of the compound was characterized by ^1H NMR, MS and elemental analysis. The binding constants （K） of complex with nucleotides and the catalytic hydrolysis of PNPP （p-nitrophenyl picolinate） were investigated by UV- visible spectrometer. The results indicated that the supramolecular assembly forms stable 1：1 or 1：2 between the complex and the guests, the hiuding constaut of 2＇ -Deoxyguanosine （ dG ） and the complex is the highest （ K = 31917 dm^3. mol^-1 ）. The hydrolysis rate of the PNPP was 25 fold of that in natural conditions.

关 键 词：大环四胺 苯并咪唑 锌配合物 超分子识别 PNPP 

分 类 号：O621.2[理学—有机化学]