丹皮酚的新法制备及其糖苷化衍生物的合成  

Novel preparation of paeonol and synthesis of its glycosylated derivatives

作　　者：程杰[1] 方志杰[1] 姜宇华[1] 郑保辉[1] 焦岩[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《化学研究与应用》2009年第10期1469-1472,共4页Chemical Research and Application

摘　　要：A novel one-step method for synthesis of paeonol,which was prepared from m-methoxyl phenol and acetic acid under catalyst of ZnCl2,with yield 68% was reported in this article.In addition,in order to improve water-solubility of paeonol,the glycosylation reactions of paeonol and 2,4-dihydroxyphenyl ethanone,which was metabolized intermediate of paeonol in organism,were carried out to modify their structures.Four glycosylation derivatives of paeonol and 2,4-dihydroxyphenyl ethanone reacted with α-bromide tetra-O-acetly-glucopyranose and α-bromide tetra-O-acetly-galactopyranose were synthesized,with yield 30-73%.Paeonol and its glycosylation derivatives were characterized by1HNMR.A novel one-step method for synthesis of paeonol,which was prepared from m-methoxyl phenol and acetic acid under catalyst of ZnCl2, with yield 68% was reported in this article. In addition, in order to improve water-solubility of paeonol, the glycosylation reactions of paeonol and 2,4-dihydroxyphenyl ethanone, which was metabolized intermediate of paeonol in organism, were carried out to modify their structures. Four glycosylation derivatives of paeonol and 2,4-dihydroxyphenyl ethanone reacted with a-bromide tetra-O-acedy-ghtcopyranose and a-bromide tetra-O-aeedy-galactopyranose were synthesized, with yield 30-73%. Paeonol and its glyeosylation derivatives were characterized by^1 HNMR.

关 键 词：丹皮酚 2 4-二羟基苯乙酮 糖苷化衍生物 结构修饰 

分 类 号：O614.3[理学—无机化学]