C反应蛋白与高血压左室重构关系的临床探讨  

Relationship between C-reactive protein and left ventricular remodeling in patients with essential hypertension

作　　者：姚宗芹[1] 陈弹[1] 蒋廷波[1] 杨俊华[1] 刘志华[1] 宋建平[1] 杨向军[1] 

机构地区：[1]苏州大学附属第一医院心血管内科,江苏苏州215006

出　　处：《西南国防医药》2009年第10期975-977,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:探讨原发性高血压(EH)患者左室重构与C反应蛋白(CRP)的关系及影响其水平的临床指标。方法:所有研究对象114例包括EH组81例和健康对照组33例。EH组行彩色多普勒超声心动图检查,根据左室重量指数(LVMI)将EH患者分为增高组和正常组两组,分别测定两组的血清C反应蛋白(CRP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿素氮(BUN)、肌酐(CR)、尿酸(UA)及血钾(K+)水平。结果:高血压组与健康对照组血清CRP水平之间差异显著(P<0.05);LVMI增高组与LVMI正常组血清C反应蛋白水平之间差异显著(P<0.05),前者显著增高,且随着LVMI的增加,C反应蛋白呈上升趋势。C反应蛋白与TG、CR、室间隔厚度、左室后壁厚度、左室舒张末期内径呈正相关,与EF呈负相关(P<0.05)。结论:(1)血清CRP浓度与EH相关,提示炎症反应可能参与了EH的发生;(2)CRP是EH患者合并左室重构的独立预测指标,它在左室重构的发生发展中可能起了一定作用。Objective ：To explore the relationship between C -reactive protein（CRP） and left ventricular reconstruction in patients with essential hypertension（EH） , and to analyze some clinical markers which could affect CRP level. Methods ：A total of 114 subjects including 81 cases of EH and 33 cases of healthy subjects were enrolled in this study. Patients with EH received color Doppler echocardiography. According to left ventricular mass index（LVMI） ,these EH patients were divided into two groups：group I with normal LVMI and group IX with high LVMI. Serum levels of C - reactive protein （ CRP）, total cholesterol （ TC ）, triglyceride （ TG）, high density lipoprotein cholesterol （ HDL - C ）, low density lipoprotein cholesterol （LDL- C ）, urea nitrogen, creatinine, uric acid and kalium were measured in all subjects, respectively. Results： Serum level of CRP was significantly higher in patients with EH than those of controls（ P 〈 0.05 ） and it was significantly higher in the patients of group Ⅱ than those of group Ⅰ （ P 〈 0.05 ）. With the increase of LVMI, CRP level appeared to increase. CRP level had a positive correlation with TG, CR, interventricular septal thickness（IVST） , left ventricle posterior wall thickness（LVPWT） and left ventricular end - diastole diameter （LVEDd） , while it showed a negative correlation with ejection fraction（EF） （ P 〈 0.05 ）. Conclusion： （ 1 ） serum level of CRP has a correlation with EH, which indicates that inflammation may be involved in the occurrence of hypertension. （：2）CRP is an independent predicted index to EH patients complicated with left ventricular reconstruction and it may play some roles in the occurrence and development of left ventricular reconstruction.

关 键 词：C反应蛋白 原发性高血压 左室重构 左室重量指数 炎症反应 

分 类 号：R544.1[医药卫生—心血管疾病]