动态血糖监测在初诊2型糖尿病患者中的应用  

The Application of continuous glucose monitoring system(CGMS) in newly diagnosed type 2 diabetes mellitus

作　　者：张勤[1] 黄恋川[1] 李伟[1] 吴桐[1] 

机构地区：[1]成都市第一人民医院内分泌科,四川成都610000

出　　处：《西部医学》2009年第10期1659-1661,共3页Medical Journal of West China

摘　　要：目的应用动态血糖系统(CGMS)观察初诊2型糖尿病(T2DM)患者中甘精胰岛素(来得时)治疗的疗效和安全性。方法T2DM患者65例,分别接受甘精胰岛素和中性鱼精蛋白锌胰岛素(NPH)治疗10周,治疗结束即时进行72 h CGMS观察。结果10周时甘精胰岛素组糖化血红蛋白(HbA1C)显著低于NPH组[(7.2±0.7)%vs(7.8±0.9)%]。CGMS检查显示,甘精胰岛素组早餐后[(9.3±2.2)mmol/L vs(10.3±2.7)mmol/L]中餐后[(8.3±2.0)mmol/L vs(9.1±1.8)mmol/L]和晚餐后2 h[(8.1±2.1)mmol/L vs(8.9±2.3)mmol/L]降低更明显,血糖≥10mmol/L间百分比明显降低[(13.5±9.1)%vs(18.7±10.4)%],凌晨3点PG不过低[(5.1±0.7)mmol/L vs(4.0±0.9)mmol/L]。甘精胰岛素组夜间低血糖发生率(1例次)显著少于NPH组(3例次),夜间血糖≤3.0 mmo/L时间百分比亦明显减少[(1.83±1.25)%vs(5.08±1.23)%]。结论甘精胰岛素治疗更接近生理胰岛素分泌模式,更好地控制24小时血糖,减少低血糖发生。Objective To observe the therapeutic effect and safety of insulin glargine in newly diagnosed type 2 dia- betes mellitus with continuous glucose monitoring system （CGMS）. Methods 65 patients were randomly divided into two groups and treated with insulin glargine and NPH, respectively. Results The level of HbAIC in glargine group was lower than that in NPH group. Blood glucose level after meal and the percentage of sugar over than 10mmol/L in glargine group were lower than that in NPH group. The incidence of hypoglycemia during the night in ~largine group was lower than that in NPH group. The percentage of night sugar level lower than 3.0 mmo/L was reduced largely in glargine group. Conclusion Insulin glargine therapy is more closed to the physiological insulin secretion model.

关 键 词：动态血糖监测系统 甘精胰岛素 中性鱼精蛋白锌胰岛素 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌]