当归提取物对急性心肌梗死大鼠的保护作用  

Protective Effect of Angelica Extract on the Acute Myocardial Infarction in Rats

作　　者：宋敏[1] 黎七雄[1] 

机构地区：[1]武汉大学医学部药理学系,430071

出　　处：《医药导报》2009年第10期1251-1253,共3页Herald of Medicine

摘　　要：目的观察当归提取物对大鼠急性心肌梗死的保护作用。方法通过结扎大鼠冠状动脉左前降支建立大鼠急性心肌梗死模型,观察当归提取物对急性心肌梗死的保护作用。60只大鼠随机分成6组:假手术组、模型组、阳性对照组、低剂量药物组、中剂量药物组、高剂量药物组,每组10只。低中、、高剂量药物组分别腹腔注射当归提取物0.07,0.14,0.28 g.kg-1,qd,连续7 d;阳性对照组腹腔注射1,6二磷酸果糖注射液1.4 g.kg-1,给药容积为10 mL.kg-1,qd,连续7 d;模型组和假手术组分别腹腔注射等量0.9%氯化钠溶液,qd,连续7 d。结果当归提取物可缩小大鼠心肌梗死范围,减少心肌细胞内肌酸激酶(CK)和乳酸脱氢酶(LDH)的释放,增强心肌凋亡相关蛋白Bc1-2的表达,减少Bax表达。结论当归提取物对大鼠急性心肌梗死有明显的保护作用。Objective To observe the protective effect of Angelica extract on the acute myocardial infarction in rats. Methods Animal model of aente myocardial infarction were established by ligating the left anterior descending coronary artery of rats. 60 rats were randomly divided into 6 groups： sham operation, model control, positive control, low dose of extraets, middle dose of extracts and high dose of extracts groups. Rats in the extracts treated groups were i.p. injected with Angelica extract 0.07, 0. 14,0.28 g·kg^-1 ,qd,for consecutive 7days; in positive control were i.p. injectod with 1.4 g·kg^-1 1,6-fruetese diphosphate at 10 mL ·kg^-1 ,qd,for 7days; rats in others were treated with normal saline at the same volume in the same way and duration. Results Angelica extract redueed the irffaret area of acute myocardial infarction,decreased the release of creative kinase（CK） and lactate dehydrogenase （LDH）. It also up-regulated the expression of Bcl-2 and clown-regulated the expression of Bax. Conclusion The result indicates that Angelica extract could protect the acute myocardial infarction in rats significantly.

关 键 词：当归提取物 心肌梗死 肌酸激酶 乳酸脱氢酶 BCL-2/BAX 

分 类 号：R965[医药卫生—药理学]