三维适形放射治疗联合参芪扶正注射液治疗非小细胞肺癌46例  

Shenqifuzheng Injection Combined with 3-Dimenation Conformal Radiotherapy for 46 Cases of Advanced Non-small Cell Lung Cancer

作　　者：谢忆山[1] 张一桥[1] 王蕊[2] 

机构地区：[1]武汉大学人民医院肿瘤科,武汉430060 [2]武汉大学人民医院急诊科,武汉430060

出　　处：《医药导报》2009年第10期1290-1292,共3页Herald of Medicine

摘　　要：目的评价参芪扶正注射液在非小细胞肺癌三维适形放射治疗(放疗)中的治疗作用。方法97例未行手术切除的中晚期非小细胞肺癌患者随机分为治疗组46例和对照组51例。全组患者均采用6MV-X线三维适形技术放疗,放疗剂量为DT60～70 Gy/6～7周,治疗组放疗期间,静脉滴注参芪扶正注射液250 mL,qd。评价两组放疗后的近期疗效,以及急性放射性肺炎、食道炎和骨髓抑制差异性。结果全组病例完全缓解(CR)率为11.3%(11/97),部分缓解(PR)率为46.4%(45/97),总有效率为57.7%(CR+PR)。两组比较近期疗效差异无显著性(P>0.05)。两组病例2级以上急性放射性肺炎、放射性食道炎和骨髓抑制反应发生率分别为6.5%,21.7%,13.0%和21.6%,25.5%,31.4%。治疗组急性放射性肺炎和骨髓抑制发生率显著低于对照组(P<0.05)。结论三维适形放疗联合参芪扶正注射液治疗肺癌较单纯放疗毒性反应明显减轻,而近期疗效无差异。Objective To evaluate the therapeutic efficacy of shenqifuzheng injection combined with 3-dimenation conformal radiotherapy（3D-CRT） for patients with advanced non-small cell lung cancer. Methods 97 eligible patients without operation were randomized into two groups, 46 in the treatment group and 51 in the control group. All patients received 3 D-CRT for 60 -70 Gy/6 to 7 weeks. During radiation, patients in thetreatment group were intravenously dripped with 250 mL, qd shenqifuzheng injection additionally. The short-time curative effect and the acute radiation pneumonitis, esophagitis and myelosuppression in both groups were compared. Results The complete recovery （CR） and partly recovery （PR） rates were 11.3% （ 11/97 ） and 46.4% （45/97） in all patients. The overall response rate （ CR ＋ PR ） was 57.7% , and no differences were found between two groups （ P 〉 0.05 ）. The incidences of 2 and 3 grade＇s acute radiation pneumonitis, esophgitis and hemotologic toxicity occurred in the treatment group and the control group were 6.5% ,21.7%, 13.0% and 21.6% ,25.5%, 31.4%, respectively. The incidence of acute radiation pneumonitis and hemotologic toxicity in control group was significantly high than those in treatmentgroup （P 〈 0.05）. Conclusion Shenqifuzheng injection combined with 3D-CRT decreases the acute radiation-induced injury without changing the short-time curative effect in treating advanced non-small cell lung cancer.

关 键 词：参芪扶正注射液 放射治疗 三维适形 肺癌 非小细胞 

分 类 号：R286[医药卫生—中药学] R734.2[医药卫生—中医学]