阿司匹林双嘧达莫胃内漂浮片的药动学及相对生物利用度的研究  

Studies on Pharmacokinetics and Relative Bioavailability of Aspirin-dipyridamole Floating Tablets in Stomach

作　　者：张军[1] 李艳梅[2] 邓树海[3] 

机构地区：[1]山东省淄博职业学院制药与生物工程系,255314 [2]山东淄博实验中学,淄博市255090 [3]山东大学药学院药物制剂研究所,山东省济南市250012

出　　处：《曲阜师范大学学报（自然科学版）》2009年第4期93-96,共4页Journal of Qufu Normal University(Natural Science)

基　　金：山东省高等学校优秀青年教师国内访问学者项目

摘　　要：采用随机交叉分组实验设计,给6条家犬分别口服单剂量阿司匹林普通片、双嘧达莫缓释胶囊和阿司匹林双嘧达莫胃内漂浮片,以HPLC法测定血浆药物浓度,采用3P97药物动力学程序计算药动学参数,统计分析显示:参比制剂和受试制剂的阿司匹林各主要药动学参数均有显著性差异,双嘧达莫各主要药动学参数无显著性差异,阿司匹林双嘧达莫胃内漂浮片具有明显的缓释特征,生物利用度具有生物等效性.In a randomized two-way cross-over design, aspirin common tablets, dipyridamole sustained release capsules and aspirin-dipyridamole floating tablets, respectively, were given to 6 male dogs in po. A rapid and sensitive HPLC assay was used for determining the drug levels in plasma, the Pharmacokinetic parameters were computed by software program 3 P97. The statistical analysis showed that there were significant differences between the main Pharmacokinetic parameters of aspirin of reference and test preparations, but there were no significant differences between the main Pharmacokinetic parameters of dipyridamole of them, the aspirin-dipyridamole floating tablets were sustained, the bioavailability of them was bioequivalence.

关 键 词：阿司匹林 双嘧达莫 胃内漂浮片 药动学 生物利用度 生物等效性 

分 类 号：R943[医药卫生—药剂学]