诺迪康对急性心肌梗死患者介入治疗后心肌保护作用的研究  

The protective effect of nuo-di-kang on myocardium after primary percutaneous coronary intervention in acute myocardial infarction

作　　者：赵强[1] 吴同果[1] 陈思伟[1] 赵进[1] 林梓卿[1] 蒋作锋[1] 

机构地区：[1]广州市红十字会医院/暨南大学附属第四医院心血管内科510220

出　　处：《国际医药卫生导报》2009年第13期6-9,共4页International Medicine and Health Guidance News

基　　金：2007年度广州市中医药和中西医结合科技项目（A2007818）

摘　　要：目的探讨诺迪康对急性心肌梗死（AMI）患者介入治疗后的心肌保护作用及其可能的机制。方法选择成功行急诊经皮冠状动脉介入治疗（PCI）的AMI患者76例，随机分为对照组（常规药物治疗）和诺迪康组（同时加用诺迪康胶囊），每组各38例患者，共治疗6个月。PCI术后24h内、第6个月时行超声心动图测定左室舒张末期内径（LVEDD）、左室射血分数（LVEF）和室壁节段运动评分指数（WMSI）。同时测定血一氧化氮（NO）、内皮素（ET）、还原型谷胱甘肽（GSH）和超氧化物歧化酶（SOD）水平。结果对照组有37例患者人选，诺迪康组有36例患者入选。PCI术后6个月时，与对照组相比，诺迪康组的LVEDD显著缩小（P〈0．05）、LVEF显著升高（P〈0．01），WMSI显著降低（P〈0．01）；血ET水平显著降低（P〈0．05），血NO（P〈0．05）、GSH（P〈0．01）和SOD（P〈0．01）水平显著升高。结论诺迪康对急性心肌梗死PCI术后患者有显著的心肌保护作用，其机制可能是通过抗血管内皮损伤和抗过氧化损伤而实现的。Objective To explore the protective effect Nuo-di-kang on myocardium after primary percutaneous coronary intervention （PCI） in patients with acute myocardial infarction （AMI） and possible mechanism. Methods 76 patients with AMI were treated with primary PCI. The patients were randomly received routine drugs （control group, n=38） or routine drugs plus Nuo-di-kang capsule （Nuo-di-kang group, n=38） for six months. Echocardiographic examinations were performed to observe the changes of left ventricular end-diastolic dimension （LVEDD）, left ventricular ejection fraction （LVEF） and wall motion score index （WMSI） on 1st day and 6th month after PCI. At the same time, the levels of blood nitricoxide （NO）, endothelin （ET）, reduced glutathione （GSH） and superoxide dis-mutase （SOD） were also measured. Results The total study population consisted of 73 patients. Compared with the control group （n=37）, LVEDD and WMSI were significant decreased （P 〈 0.05, P 〈 0.01）, whereas LVEF significant increased （P〈 0.01） in Nuo-di-kang group （n=36） six month after PCI. Compared with the control group, the level of ET was significantly decreased （P〈 0.05）, the levels of NO, GSH and SOD were significant increased （P 〈 0.05, P 〈 0.01）. Conclusion Nao-di-kang has protective effect on myocardium after primary PCI in patients with AMI. The beneficial effect of Nuo-di-kang may due to its resistance to endothelial injury and oxidative damage.

关 键 词：心肌梗死 经皮冠状动脉血管成形术 心肌 诺迪康胶囊 

分 类 号：R542[医药卫生—心血管疾病]