2006至2008年间某医院感染病原菌谱及其耐药性分析  

Spectra of Clinical Pathogenic Bacterial Isolates and Their Resistance Variation in Our Hospital Infection from 2006 to 2008

作　　者：郑江花[1] 肖勇健[1] 

机构地区：[1]南华大学第二附属医院检验科,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2009年第4期420-422,429,共4页Journal of Nanhua University(Medical Edition)

摘　　要：目的了解、分析桌医院在2006-2008年间临床分离病原菌的分布及其耐药情况。方法对2006-2008年期间某医院临床微生物室分离到的病原菌，用K-B琼脂扩散法药敏试验的抑茵圈直径输入计算机，采用WHONET5.3软件进行统计分析，根据美国临床实验室标准化协会（CLSI）2006年标准判定其耐药性。结果在此3年间革兰阳性菌检出构成比稍有上升趋势，而革兰阴性菌略有下降趋势；葡萄球菌属对青霉素的耐药率超过93.0％，对红霉素、阿奇霉素的耐药率超过53.2％；凝固酶阴性葡萄球菌对苯唑西林的耐药率超过73.8％，明显高于金黄色葡萄球菌；肠球菌属对万古霉素的耐药率为1.0％；大肠埃希菌及克雷伯菌属对氨苄西林耐药率均很高；革兰阴性菌对亚胺培南及美罗培南开始出现耐药。结论某医院于2006-2008年间检出病原菌存在严重耐药，及时监测病原菌变化及其耐药趋势以指导临床用药非常重要。Objective To investigate the distribution of clinical bacterial isolates and the change in antibiotic resistance spectrum in our hospital from 2006 to 2008. Method Data of bacterial susceptibility testing of clinical isolates from one hospital from 2006 to 2008 were collected and analyzed by software WHONET5.3, and assessed according to Clinical and Laboratory Standards Institute（CLSI） issued in 2006. Result The amount of Gram negative bacteria went down and Gram positive bacteria went up during this period. The drug resistance rate of staphylococci against penieiUin and erythromycin was more than 93.0% and 53.2% , respectively. The oxacillin resistance rate of CNS was 73.8% , significandy higher than that of S. aureus 15.5%. Drug resistance rate of Enterococcus to vancomycin was 1.0%. Gram negative bacteria began to be resistant to meropenem and imipenem, whereas the resistance rate of Klebsiella and Escherichia to ampicillin was very high. Conclusion The variation of drug resistance and distribution of clinical bacterial isolates in our hospital are related to the improper use of antibiotics. It is very important to select antibiotics correctly according to the resuits of antibiotics susceptibility tests.

关 键 词：病原菌 分布 耐药性 

分 类 号：R446.5[医药卫生—诊断学]