四川省噬菌体6型霍乱流行病学调查分析  

Epidemiological Analysis of Cholera Phage Type 6

作　　者：吕强[1] 祝小平[1] 袁珩[1] 刘红露[1] 罗隆泽[1] 冯泽惠[1] 徐耀方[1] 

机构地区：[1]四川省疾病预防控制中心,四川成都610041

出　　处：《预防医学情报杂志》2009年第10期800-804,共5页Journal of Preventive Medicine Information

摘　　要：目的分析四川省噬菌体6型霍乱的流行及病原学特征,为制定防控对策提供依据。方法根据1998-2001年省噬菌体6型霍乱流行病学个案调查表、专题调查、实验室检验鉴定结果以及各地霍乱防治工作总结等资料,进行描述流行病学分析和实验室结果分析。结果1998-2008四川省出现首例噬菌体6型霍乱病例,1998-2001年累计报告6b型霍乱2 239例,死亡100例。6b型霍乱年平均发病率为0.66/10万,病死率为4.47%。疫情波及全省5个市(州)的20个县(区)。分子生物学试验:噬菌体分型6型菌株与同期流行的1型菌株完全一致,具有流行株的分子特征。结论噬菌体6型霍乱菌株具有引起霍乱流行的能力,且病死率较高。Objective To analyze the prevalence and pathogenic characteristics of cholera phage type 6 in Sichuan province and provide basis for the control measures. Methods Descriptive epidemiological analysis and laboratory analysis were conducted according to the epidemiological survey of the cases of cholera phage type 6 in Sichuan from 1998 to 2001, special survey and summary of cholera prevention and control, and the laboratory test results. Results The first case of cholera phage type 6 in Sichuan occurred in August, 1998. From 1998 to 2001, a total of 2239 cases of cholera（6b） and 100 deaths were reported with the average annual incidence rate of 0. 66/105 and case-fatality of 4. 47%. The epidemic occurred in 5 municipalities and 20 counties. Molecular biology test indicated that the phage type 6 strain was fully consistent with phage type 1 strain circulated in the same period, which had the molecular characteristics of epidemic strain. Conclusion The strain of cholera phage type 6 could cause the epidemic of cholera with high case-fatality.

关 键 词：霍乱 噬菌体生物分型 流行 控制 

分 类 号：R516.5[医药卫生—内科学]