钙与免疫细胞功能及免疫缺陷疾病的关系  

Relationships between calcium and the functions of immunocens and the immune deficiency disorders

作　　者：王俐[1] 蔡美琴[1] 

机构地区：[1]上海交通大学医学院营养系 200025

出　　处：《中华临床营养杂志》2009年第1期60-63,共4页Chinese Journal of Clinical Nutrition

摘　　要：钙是人体内含量最多的无机元素，作为一种重要的细胞间信号传导分子，在免疫细胞的功能发挥中起着重要作用。当T或B淋巴细胞的T细胞受体或B细胞受体受到刺激及其他协同刺激信号刺激细胞之后，Ca^2＋可内流进入淋巴细胞，引起瞬时性或长时性的细胞内Ca^2＋浓度升高。Ca^2＋信号又可对T、B淋巴细胞产生不同的瞬时、长时效应。多种免疫缺陷性疾病与Ca。’内流障碍有关。本文就a^2 ＋对T、B淋巴细胞的作用以及Ca^2＋与某些免疫缺陷疾病性的关系做一综述。Calcium, as a crucial signal molecule, plays an important role in the development process of immune cells and their functions. After T cell receptors or B cell receptors are stimulated or co-stimulated, the signaling pathways lead to Ca^2＋ influx and induce the increase of Ca^2＋ level in cells. Ca^2＋ signals have different short-time and longterm functions on T and B lymphocytes. Many immune deficiency disorders are resulted from the decrease of Ca^2 ＋ influx. This article reviewed the effects of calcium on the functions of T and B lymphocytes and its relationship with some immune deficiency disorders.

关 键 词：钙 免疫细胞 免疫缺陷性疾病 

分 类 号：R593[医药卫生—内科学]